Editing Cancer research (section)

== Diet and cancer ==
{{Excerpt|Diet and cancer}}
Periods of [[intermittent fasting]] (time-restricted feeding which may not include [[caloric restriction]]) is investigated for potential usefulness in cancer prevention and treatment and as of 2021 additional trials are needed to elucidate the risks and benefits.<ref>{{cite journal |last1=Clifton |first1=Katherine K. |last2=Ma |first2=Cynthia X. |last3=Fontana |first3=Luigi |last4=Peterson |first4=Lindsay L. |title=Intermittent fasting in the prevention and treatment of cancer |journal=CA: A Cancer Journal for Clinicians |date=November 2021 |volume=71 |issue=6 |pages=527–546 |doi=10.3322/caac.21694 |pmid=34383300 |s2cid=236989849 |language=en |issn=0007-9235}}</ref><ref>{{cite journal |last1=Manoogian |first1=Emily N. C. |last2=Panda |first2=Satchidananda |title=Circadian rhythms, time-restricted feeding, and healthy aging |journal=Ageing Research Reviews |date=1 October 2017 |volume=39 |pages=59–67 |doi=10.1016/j.arr.2016.12.006 |pmid=28017879 |pmc=5814245 |language=en |issn=1568-1637}}</ref><ref>{{cite book |last1=Brandhorst |first1=Sebastian |last2=Longo |first2=Valter D. |title=Metabolism in Cancer |chapter=Fasting and Caloric Restriction in Cancer Prevention and Treatment |series=Recent Results in Cancer Research |date=2016 |volume=207 |pages=241–266 |doi=10.1007/978-3-319-42118-6_12 |publisher=Springer |pmid=27557543 |pmc=7476366 |isbn=978-3-319-42116-2 |s2cid=42198775 |language=en}}</ref><ref>{{cite journal |last1=Alidadi |first1=Mona |last2=Banach |first2=Maciej |last3=Guest |first3=Paul C. |last4=Bo |first4=Simona |last5=Jamialahmadi |first5=Tannaz |last6=Sahebkar |first6=Amirhossein |title=The effect of caloric restriction and fasting on cancer |journal=Seminars in Cancer Biology |date=1 August 2021 |volume=73 |pages=30–44 |doi=10.1016/j.semcancer.2020.09.010 |pmid=32977005 |s2cid=221938415 |language=en |issn=1044-579X}}</ref> In some cases, "caloric restrictions could hinder both cancer growth and progression, besides enhancing the efficacy of chemotherapy and radiation therapy".<ref>{{cite journal |last1=Ibrahim |first1=Ezzeldin M. |last2=Al-Foheidi |first2=Meteb H. |last3=Al-Mansour |first3=Mubarak M. |title=Energy and caloric restriction, and fasting and cancer: a narrative review |journal=Supportive Care in Cancer |date=1 May 2021 |volume=29 |issue=5 |pages=2299–2304 |doi=10.1007/s00520-020-05879-y |pmid=33190181 |pmc=7981322 |s2cid=226945778 }}</ref> [[Caloric restriction mimetic]]s, including some present in foods like [[spermidine]], are also investigated for these or similar reasons.<ref>{{cite journal |last1=Hofer |first1=Sebastian J. |last2=Davinelli |first2=Sergio |last3=Bergmann |first3=Martina |last4=Scapagnini |first4=Giovanni |last5=Madeo |first5=Frank |title=Caloric Restriction Mimetics in Nutrition and Clinical Trials |journal=Frontiers in Nutrition |date=2021 |volume=8 |page=717343 |doi=10.3389/fnut.2021.717343 |pmid=34552954 |pmc=8450594 |doi-access=free }}</ref><ref>{{cite journal |last1=Madeo |first1=Frank |last2=Eisenberg |first2=Tobias |last3=Pietrocola |first3=Federico |last4=Kroemer |first4=Guido |title=Spermidine in health and disease |journal=Science |date=26 January 2018 |volume=359 |issue=6374 |pages=eaan2788 |doi=10.1126/science.aan2788 |pmid=29371440 |s2cid=206659415 |language=en |issn=0036-8075|doi-access=free }}</ref> Such and similar [[dietary supplement]]s may contribute to prevention or treatment, with candidate substances including [[apigenin]],<ref>{{cite journal |last1=Imran |first1=Muhammad |last2=Aslam Gondal |first2=Tanweer |last3=Atif |first3=Muhammad |last4=Shahbaz |first4=Muhammad |last5=Batool Qaisarani |first5=Tahira |last6=Hanif Mughal |first6=Muhammad |last7=Salehi |first7=Bahare |last8=Martorell |first8=Miquel |last9=Sharifi-Rad |first9=Javad |title=Apigenin as an anticancer agent |journal=Phytotherapy Research |date=August 2020 |volume=34 |issue=8 |pages=1812–28 |doi=10.1002/ptr.6647 |pmid=32059077 |s2cid=211122428 |language=en |issn=0951-418X}}</ref><ref>{{cite journal |last1=Shukla |first1=Sanjeev |last2=Gupta |first2=Sanjay |title=Apigenin: A Promising Molecule for Cancer Prevention |journal=Pharmaceutical Research |date=1 June 2010 |volume=27 |issue=6 |pages=962–978 |doi=10.1007/s11095-010-0089-7 |pmid=20306120 |pmc=2874462 }}</ref><ref>{{cite journal |last1=Shankar |first1=Eswar |last2=Goel |first2=Aditi |last3=Gupta |first3=Karishma |last4=Gupta |first4=Sanjay |title=Plant Flavone Apigenin: an Emerging Anticancer Agent |journal=Current Pharmacology Reports |date=1 December 2017 |volume=3 |issue=6 |pages=423–446 |doi=10.1007/s40495-017-0113-2 |pmid=29399439 |pmc=5791748 }}</ref> [[berberine]],<ref>{{cite journal |last1=Samadi |first1=Parisa |last2=Sarvarian |first2=Parisa |last3=Gholipour |first3=Elham |last4=Asenjan |first4=Karim Shams |last5=Aghebati-Maleki |first5=Leili |last6=Motavalli |first6=Roza |last7=Hojjat-Farsangi |first7=Mohammad |last8=Yousefi |first8=Mehdi |title=Berberine: A novel therapeutic strategy for cancer |journal=IUBMB Life |date=October 2020 |volume=72 |issue=10 |pages=2065–79 |doi=10.1002/iub.2350 |pmid=32735398 |s2cid=220893166 |language=en |issn=1521-6543|doi-access=free }}</ref><ref>{{cite journal |last1=Zhong |first1=Xiao-Dan |last2=Chen |first2=Li-Juan |last3=Xu |first3=Xin-Yang |last4=Liu |first4=Yan-Jun |last5=Tao |first5=Fan |last6=Zhu |first6=Ming-Hui |last7=Li |first7=Chang-Yun |last8=Zhao |first8=Dan |last9=Yang |first9=Guan-Jun |last10=Chen |first10=Jiong |title=Berberine as a potential agent for breast cancer therapy |journal=Frontiers in Oncology |date=2022 |volume=12 |page=993775 |doi=10.3389/fonc.2022.993775 |pmid=36119505 |pmc=9480097 |doi-access=free }}</ref><ref>{{cite journal |last1=Wang |first1=Ye |last2=Liu |first2=Yanfang |last3=Du |first3=Xinyang |last4=Ma |first4=Hong |last5=Yao |first5=Jing |title=The Anti-Cancer Mechanisms of Berberine: A Review |journal=Cancer Management and Research |date=30 January 2020 |volume=12 |pages=695–702 |doi=10.2147/CMAR.S242329 |pmid=32099466 |pmc=6996556 |doi-access=free }}</ref><ref>{{cite journal |last1=Vlavcheski |first1=Filip |last2=O’Neill |first2=Eric J. |last3=Gagacev |first3=Filip |last4=Tsiani |first4=Evangelia |title=Effects of Berberine against Pancreatitis and Pancreatic Cancer |journal=Molecules |date=January 2022 |volume=27 |issue=23 |pages=8630 |doi=10.3390/molecules27238630 |pmid=36500723 |pmc=9738201 |doi-access=free }}</ref><ref>{{cite journal |last1=Guamán Ortiz |first1=Luis Miguel |last2=Lombardi |first2=Paolo |last3=Tillhon |first3=Micol |last4=Scovassi |first4=Anna Ivana |title=Berberine, an Epiphany Against Cancer |journal=Molecules |date=August 2014 |volume=19 |issue=8 |pages=12349–67 |doi=10.3390/molecules190812349 |pmid=25153862 |pmc=6271598 |doi-access=free }}</ref> [[jiaogulan]],<ref>{{cite journal |last1=Su |first1=Chao |last2=Li |first2=Nan |last3=Ren |first3=Ruru |last4=Wang |first4=Yingli |last5=Su |first5=Xiaojuan |last6=Lu |first6=Fangfang |last7=Zong |first7=Rong |last8=Yang |first8=Lingling |last9=Ma |first9=Xueqin |title=Progress in the Medicinal Value, Bioactive Compounds, and Pharmacological Activities of Gynostemma pentaphyllum |journal=Molecules |date=January 2021 |volume=26 |issue=20 |pages=6249 |doi=10.3390/molecules26206249 |pmid=34684830 |pmc=8540791 |doi-access=free }}</ref> and [[rhodiola rosea]].<ref>{{cite journal |last1=Pu |first1=Wei-ling |last2=Zhang |first2=Meng-ying |last3=Bai |first3=Ru-yu |last4=Sun |first4=Li-kang |last5=Li |first5=Wen-hua |last6=Yu |first6=Ying-li |last7=Zhang |first7=Yue |last8=Song |first8=Lei |last9=Wang |first9=Zhao-xin |last10=Peng |first10=Yan-fei |last11=Shi |first11=Hong |last12=Zhou |first12=Kun |last13=Li |first13=Tian-xiang |title=Anti-inflammatory effects of Rhodiola rosea L.: A review |journal=Biomedicine & Pharmacotherapy |date=1 January 2020 |volume=121 |pages=109552 |doi=10.1016/j.biopha.2019.109552 |pmid=31715370 |s2cid=207938536 |language=en |issn=0753-3322|doi-access=free }}</ref><ref>{{cite journal |last1=Magani |first1=Sri Krishna Jayadev |last2=Mupparthi |first2=Sri Durgambica |last3=Gollapalli |first3=Bhanu Prakash |last4=Shukla |first4=Dhananjay |last5=Tiwari |first5=A. K. |last6=Gorantala |first6=Jyotsna |last7=Yarla |first7=Nagendra Sastry |last8=Tantravahi |first8=Srinivasan |title=Salidroside — Can it be a Multifunctional Drug? |journal=Current Drug Metabolism |year=2020 |volume=21 |issue=7 |pages=512–524 |doi=10.2174/1389200221666200610172105 |pmid=32520682 |s2cid=219588131 |language=en}}</ref>