Editing Cleft lip and cleft palate (section)

====Specific genes====
{| class="wikitable" style = "float: right; margin-left:15px; text-align:center"
|-
! Type
! [[OMIM]]
! Gene
! Locus
|-
| OFC1
| {{OMIM|119530||none}}
| ?
| 6p24
|-
| OFC2
| {{OMIM|602966||none}}
| ?
| 2p13
|-
| OFC3
| {{OMIM|600757||none}}
| ?
| 19q13
|-
| OFC4
| {{OMIM|608371||none}}
| ?
| 4q
|-
| OFC5
| {{OMIM|608874||none}}
| ''[[MSX1]]''
| 4p16.1
|-
| OFC6
| {{OMIM|608864||none}}
| ?
| 1q
|-
| OFC7
| {{OMIM|600644)||none}}
| ''[[PVRL1]]''
| 11q
|-
| OFC8
| {{OMIM|129400||none}}
| ''[[TP63]]''
| 3q27
|-
| OFC9
| {{OMIM|610361||none}}
| ?
| 13q33.1-q34
|-
| OFC10
| {{OMIM|601912||none}}
| ''[[SUMO1]]''
| 2q32.2-q33
|-
| OFC11
| {{OMIM|600625||none}}
| ''[[BMP4]]''
| 14q22
|-
| OFC12
| {{OMIM|612858||none}}
| ?
| 8q24.3
|}

Many genes associated with syndromic cases of cleft lip/palate (see above) have been identified to contribute to the incidence of isolated cases of cleft lip/palate. This includes in particular sequence variants in the genes ''[[IRF6]]'', ''[[PVRL1]]'' and ''[[MSX1]]''.<ref name="pmid14756664">{{cite journal | vauthors = Cox TC | title = Taking it to the max: the genetic and developmental mechanisms coordinating midfacial morphogenesis and dysmorphology | journal = Clinical Genetics | volume = 65 | issue = 3 | pages = 163–176 | date = March 2004 | pmid = 14756664 | doi = 10.1111/j.0009-9163.2004.00225.x | s2cid = 22472334 }}</ref> The understanding of the genetic complexities involved in the [[morphogenesis]] of the midface, including molecular and cellular processes, has been greatly aided by research on animal models, including of the genes ''[[BMP4]]'', ''SHH'', ''SHOX2'', ''[[FGF10]]'' and ''[[MSX1]]''.<ref name="pmid14756664" />