Editing Cyclodextrin (section)

==Safety==
Cyclodextrins are of wide interest in part because they appear [[Toxicity|nontoxic]] in [[animal studies]]. The [[LD50]] (oral, rats) is on the order of grams per kilogram.<ref name=Ullmann/> Nevertheless, attempts to use β-cyclodextrin for the prevention of [[atherosclerosis]],<ref>{{cite journal | vauthors = Zimmer S, Grebe A, Bakke SS, Bode N, Halvorsen B, Ulas T, Skjelland M, De Nardo D, Labzin LI, Kerksiek A, Hempel C, Heneka MT, Hawxhurst V, Fitzgerald ML, Trebicka J, Björkhem I, Gustafsson JÅ, Westerterp M, Tall AR, Wright SD, Espevik T, Schultze JL, Nickenig G, Lütjohann D, Latz E | title = Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming | journal = Science Translational Medicine | volume = 8 | issue = 333 | pages = 333ra50 | date = April 2016 | pmid = 27053774 | pmc = 4878149 | doi = 10.1126/scitranslmed.aad6100 }}</ref> age-related [[lipofuscin]] accumulation<ref name="pmid28526856">{{cite journal | vauthors = Gaspar J, Mathieu J, Alvarez P | title = 2-Hydroxypropyl-beta-cyclodextrin (HPβCD) reduces age-related lipofuscin accumulation through a cholesterol-associated pathway | journal = Scientific Reports | volume = 7 | issue = 1 | pages = 2197 | date = May 2017 | pmid = 28526856 | pmc = 5438378 | doi = 10.1038/s41598-017-02387-8 | bibcode = 2017NatSR...7.2197G }}</ref> and [[obesity]] encounter an obstacle in the form of damage to the [[Cochlear nerve|auditory nerve]]<ref name="pmid23285273">{{cite journal | vauthors = Crumling MA, Liu L, Thomas PV, Benson J, Kanicki A, Kabara L, Hälsey K, Dolan D, Duncan RK | title = Hearing loss and hair cell death in mice given the cholesterol-chelating agent hydroxypropyl-β-cyclodextrin | journal = PLOS ONE | volume = 7 | issue = 12 | pages = e53280 | date = 2012 | pmid = 23285273 | pmc = 3532434 | doi = 10.1371/journal.pone.0053280 | doi-access = free | bibcode = 2012PLoSO...753280C }}</ref> and [[Nephrotoxicity|nephrotoxic]] effect.<ref>{{cite journal | vauthors = Scantlebery AM, Ochodnicky P, Kors L, Rampanelli E, Butter LM, El Boumashouli C, Claessen N, Teske GJ, van den Bergh Weerman MA, Leemans JC, Roelofs JJ, Florquin S | title = β-Cyclodextrin counteracts obesity in Western diet-fed mice but elicits a nephrotoxic effect | journal = Scientific Reports | volume = 9 | issue = 1 | pages = 17633 | date = November 2019 | pmid = 31776357 | pmc = 6881402 | doi = 10.1038/s41598-019-53890-z | bibcode = 2019NatSR...917633S }}</ref>