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Food intolerance
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==History== In 1978 Australian researchers published details of an 'exclusion diet' to exclude specific food chemicals from the diet of patients. This provided a basis for challenge with these additives and natural chemicals. Using this approach the role played by dietary chemical factors in the pathogenesis of [[chronic idiopathic urticaria]] (CIU) was first established and set the stage for future DBPCT trials of such substances in food intolerance studies.<ref name="pmid661687"> {{cite journal |vauthors=Gibson AR, Clancy RL |s2cid=8897411 |title=An Australian exclusion diet |journal=Med J Aust |volume=1 |issue=5 |pages=290β2 |date=March 1978 |pmid=661687 |doi= 10.5694/j.1326-5377.1978.tb112553.x}}</ref><ref name="pmid7460264"> {{cite journal |vauthors=Gibson A, Clancy R |s2cid=12346266 |title=Management of chronic idiopathic urticaria by the identification and exclusion of dietary factors |journal=Clinical & Experimental Allergy |volume=10 |issue=6 |pages=699β704 |date=November 1980 |pmid=7460264 |doi=10.1111/j.1365-2222.1980.tb02154.x }}</ref> In 1995 the European Academy of Allergology and Clinical Immunology suggested a classification on the basis of the responsible pathogenetic mechanism; according to this classification, non-toxic reactions can be divided into 'food allergies' when they recognize immunological mechanisms, and 'food intolerances' when there are no immunological implications. Reactions secondary to food ingestion are defined generally as 'adverse reactions to food'.<ref name="pmid18431058"> {{cite journal |author=Montalto M |title=Adverse reactions to food: allergies and intolerances |journal=Dig Dis |volume=26 |issue=2 |pages=96β103 |year=2008 |pmid=18431058 |doi=10.1159/000116766 |name-list-style=vanc|author2=Santoro L |author3=D'Onofrio F |display-authors=3 |last4=Curigliano |first4=Valentina |last5=Gallo |first5=Antonella |last6=Visca |first6=Dina |last7=Cammarota |first7=Giovanni |last8=Gasbarrini |first8=Antonio |last9=Gasbarrini |first9=Giovanni|hdl=11383/2076128 |s2cid=10055914 |hdl-access=free }}</ref> In 2003 the Nomenclature Review Committee of the World Allergy Organization issued a report of revised nomenclature for global use on food allergy and food intolerance, that has had general acceptance. Food intolerance is described as a 'non-allergic hypersensitivity' to food.<ref> {{cite journal |author=Johansson SG |title=Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003 |journal=The Journal of Allergy and Clinical Immunology |volume=113 |issue=5 |pages=832β6 |date=May 2004 |pmid=15131563 |doi=10.1016/j.jaci.2003.12.591 |name-list-style=vanc|author2=Bieber T |author3=Dahl R |display-authors=3 |last4=Friedmann |first4=Peter S |last5=Lanier |first5=Bobby Q |last6=Lockey |first6=Richard F |last7=Motala |first7=Cassim |last8=Ortega Martell |first8=Jose A |last9=Platts-Mills |first9=Thomas A.E|doi-access=free }}</ref>
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