Editing Gap junction (section)

====Tissue restructuring====
While there has been a tendency to focus on the bystander effect in disease due to the possibility of therapeutic avenues, there is evidence that there is a more central role in normal development of tissues. Death of some cells and their surrounding matrix may be required for a tissue to reach its final configuration; gap junctions appear essential to this process.<ref>{{cite journal | pmid = 12878681 | pmc=6740641 | volume=23 | issue=16 | title=Gap junctions mediate bystander cell death in developing retina |date=July 2003 | journal=J. Neurosci. | pages=6413–22 | last1 = Cusato | first1 = K | last2 = Bosco | first2 = A | last3 = Rozental | first3 = R | last4 = Guimarães | first4 = CA | last5 = Reese | first5 = BE | last6 = Linden | first6 = R | last7 = Spray | first7 = DC| doi=10.1523/JNEUROSCI.23-16-06413.2003 }}</ref><ref>{{cite journal | pmid = 15225205 | doi=10.1111/j.1067-1927.2004.012310.x | volume=12 | issue=3 | title=Mast cells promote fibroblast populated collagen lattice contraction through gap junction intercellular communication | year=2004 | journal=Wound Repair Regen | pages=269–75 | last1 = Moyer | first1 = Kurtis E. | last2 = Saggers | first2 = Gregory C. | last3 = Ehrlich | first3 = H. Paul| s2cid=24363587 }}</ref> There are also more complex studies that try to combine our understanding of the simultaneous roles of gap junctions in both wound healing and tissue development.<ref>{{cite journal | pmid = 16628254 | doi=10.1172/JCI27186 | pmc=1440704 | volume=116 | issue=5 | title=Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response |date=May 2006 | journal=J. Clin. Invest. | pages=1243–53 | last1 = Djalilian | first1 = A. R. | last2 = McGaughey | first2 = D | last3 = Patel | first3 = S | last4 = Seo | first4 = EY | last5 = Yang | first5 = C | last6 = Cheng | first6 = J | last7 = Tomic | first7 = M | last8 = Sinha | first8 = S | last9 = Ishida-Yamamoto | first9 = A| last10=Segre | first10=J. A. | display-authors=8 }}</ref><ref>{{cite journal | pmid = 19966054 | doi=10.1152/ajpheart.00806.2009 | pmc=2822575 | volume=298 | issue=2 | title=Reduced expression of Cx43 attenuates ventricular remodeling after myocardial infarction via impaired TGF-beta signaling |date=February 2010 | journal=Am. J. Physiol. Heart Circ. Physiol. | pages=H477–87 | last1 = Zhang | first1 = Y. | last2 = Wang | first2 = H. | last3 = Kovacs | first3 = A. | last4 = Kanter | first4 = E. M. | last5 = Yamada | first5 = K. A.}}</ref><ref>{{cite journal | vauthors = Ey B, Eyking A, Gerken G, Podolsky DK, Cario E | title = TLR2 mediates gap junctional intercellular communication through connexin-43 in intestinal epithelial barrier injury | journal = J. Biol. Chem. | volume = 284 | issue = 33 | pages = 22332–43 | date = August 2009 | pmid = 19528242 | doi = 10.1074/jbc.M901619200 | pmc=2755956| doi-access = free }}</ref>