Editing Insulin-like growth factor 1 (section)

=== Growth hormone deficiency ===
IGF-1 levels can be analyzed and used by physicians as a [[screening test]] for [[growth hormone deficiency]] (GHD),<ref>{{cite journal | vauthors = Shen Y, Zhang J, Zhao Y, Yan Y, Liu Y, Cai J | title = Diagnostic value of serum IGF-1 and IGFBP-3 in growth hormone deficiency: a systematic review with meta-analysis | journal = European Journal of Pediatrics | volume = 174 | issue = 4 | pages = 419–427 | date = April 2015 | pmid = 25213432 | doi = 10.1007/s00431-014-2406-3 }}</ref> [[acromegaly]] and [[gigantism]].<ref name="Xq26">{{cite journal | vauthors = Trivellin G, Daly AF, Faucz FR, Yuan B, Rostomyan L, Larco DO, Schernthaner-Reiter MH, Szarek E, Leal LF, Caberg JH, Castermans E, Villa C, Dimopoulos A, Chittiboina P, Xekouki P, Shah N, Metzger D, Lysy PA, Ferrante E, Strebkova N, Mazerkina N, Zatelli MC, Lodish M, Horvath A, de Alexandre RB, Manning AD, Levy I, Keil MF, Sierra M, Palmeira L, Coppieters W, Georges M, Naves LA, Jamar M, Bours V, Wu TJ, Choong CS, Bertherat J, Chanson P, Kamenický P, Farrell WE, Barlier A, Quezado M, Bjelobaba I, Stojilkovic SS, Wess J, Costanzi S, Liu P, Lupski JR, Beckers A, Stratakis CA | title = Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation | journal = The New England Journal of Medicine | volume = 371 | issue = 25 | pages = 2363–2374 | date = December 2014 | pmid = 25470569 | pmc = 4291174 | doi = 10.1056/NEJMoa1408028 }}</ref> However, IGF-1 has been shown to be a bad diagnostic screening test for growth hormone deficiency.<ref>{{cite journal | vauthors = Iwayama H, Kitagawa S, Sada J, Miyamoto R, Hayakawa T, Kuroyanagi Y, Muto T, Kurahashi H, Ohashi W, Takagi J, Okumura A | title = Insulin-like growth factor-1 level is a poor diagnostic indicator of growth hormone deficiency | journal = Scientific Reports | volume = 11 | issue = 1 | pages = 16159 | date = August 2021 | pmid = 34373538 | pmc = 8352887 | doi = 10.1038/s41598-021-95632-0 | bibcode = 2021NatSR..1116159I }}</ref><ref>{{cite journal | vauthors = Fatani TH | title = Diagnostic Value of IGF-1 in Growth Hormone-Deficient Children: Is a Second Growth Hormone Stimulation Test Necessary? | journal = Journal of the Endocrine Society | volume = 7 | issue = 4 | pages = bvad018 | date = February 2023 | pmid = 36846213 | pmc = 9954969 | doi = 10.1210/jendso/bvad018 | doi-access = free }}</ref>

The ratio of IGF-1 and [[insulin-like growth factor-binding protein 3]] has been shown to be a useful diagnostic test for GHD.<ref>{{cite journal | vauthors = Haj-Ahmad LM, Mahmoud MM, Sweis NW, Bsisu I, Alghrabli AM, Ibrahim AM, Zayed AA | title = Serum IGF-1 to IGFBP-3 Molar Ratio: A Promising Diagnostic Tool for Growth Hormone Deficiency in Children | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 108 | issue = 4 | pages = 986–994 | date = March 2023 | pmid = 36251796 | doi = 10.1210/clinem/dgac609 }}</ref><ref>{{cite journal | vauthors = Lambrecht N | title = IGF-1/IGFBP-3 Serum Ratio as a Robust Measure to Determine GH Deficiency and Guide Human Recombinant GH Therapy | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 108 | issue = 4 | pages = e54–e55 | date = March 2023 | pmid = 36454697 | doi = 10.1210/clinem/dgac687 }}</ref>