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===Text mining of PPIs=== Some efforts have been made to extract systematically interaction networks directly from the scientific literature. Such approaches range in terms of complexity from simple co-occurrence statistics of entities that are mentioned together in the same context (e.g. sentence) to sophisticated natural language processing and machine learning methods for detecting interaction relationships.<ref>{{Cite journal | pmid = 15886388 | year = 2005 | last1 = Hoffmann | first1 = R | title = Text mining for metabolic pathways, signaling cascades, and protein networks | journal = Science Signaling | volume = 2005 | issue = 283 | pages = pe21 | last2 = Krallinger | first2 = M | last3 = Andres | first3 = E | last4 = Tamames | first4 = J | last5 = Blaschke | first5 = C | last6 = Valencia | first6 = A | s2cid = 15301069 | doi = 10.1126/stke.2832005pe21 }}</ref>
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