Editing Non-coding DNA (section)

===Scaffold attachment regions===
{{Main|Scaffold/matrix attachment region}}

Both prokaryotic and eukarotic genomes are organized into large loops of protein-bound DNA. In eukaryotes, the bases of the loops are called [[Scaffold/matrix attachment region|scaffold attachment regions]] (SARs) and they consist of stretches of DNA that bind an RNA/protein complex to stabilize the loop. There are about 100,000 loops in the human genome and each SAR consists of about 100 bp of DNA, so the total amount of DNA devoted to SARs accounts for about 0.3% of the human genome.<ref>{{cite journal | vauthors = Mistreli T | date = 2020 | title = The self-organizing genome: Principles of genome architecture and function | journal = Cell | volume = 183 | issue = 1 | pages = 28–45 | doi = 10.1016/j.cell.2020.09.014 | pmid = 32976797 | pmc = 7541718 }}</ref>