Editing Notch signaling pathway (section)

=== Role in epidermal differentiation ===
Notch signaling is known to occur inside ciliated, differentiating cells found in the first epidermal layers during early skin development.<ref>{{cite journal | vauthors = Lowell S, Jones P, Le Roux I, Dunne J, Watt FM | title = Stimulation of human epidermal differentiation by delta-notch signalling at the boundaries of stem-cell clusters | journal = Current Biology | volume = 10 | issue = 9 | pages = 491–500 | date = May 2000 | pmid = 10801437 | doi = 10.1016/s0960-9822(00)00451-6 | s2cid = 8927528 | doi-access = free | bibcode = 2000CBio...10..491L }}</ref> Furthermore, it has found that [[PSEN2|presenilin-2]] works in conjunction with ARF4 to regulate Notch signaling during this development.<ref>{{cite journal | vauthors = Ezratty EJ, Pasolli HA, Fuchs E | title = A Presenilin-2-ARF4 trafficking axis modulates Notch signaling during epidermal differentiation | journal = The Journal of Cell Biology | volume = 214 | issue = 1 | pages = 89–101 | date = July 2016 | pmid = 27354375 | pmc = 4932368 | doi = 10.1083/jcb.201508082 }}</ref> However, it remains to be determined whether gamma-secretase has a direct or indirect role in modulating Notch signaling.