Editing Nuclear Overhauser effect (section)

== Structure elucidation using NOESY ==
Over the last few decades, 2D-NOESY has developed into a valuable tool for the structural elucidation of molecules. 2D-NOESY is not only suitable for small molecules, but is also applicable to larger molecules.<ref>{{Cite journal |last=Darling |first=William T. P. |last2=Wieske |first2=Lianne H. E. |last3=Cook |first3=Declan T. |last4=Aliev |first4=Abil E. |last5=Caron |first5=Laurent |last6=Humphrys |first6=Emily J. |last7=Figueiredo |first7=Angelo Miguel |last8=Hansen |first8=D. Flemming |last9=Erdélyi |first9=Máté |last10=Tabor |first10=Alethea B. |date=2024 |title=The Influence of Disulfide, Thioacetal and Lanthionine-Bridges on the Conformation of a Macrocyclic Peptide |url=https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202401654 |journal=Chemistry – A European Journal |language=en |volume=30 |issue=50 |pages=e202401654 |doi=10.1002/chem.202401654 |issn=1521-3765|doi-access=free }}</ref> However, NOESY is not alone, but always combined with generation of theoretical molecular ensembles, which must be deconvoluted, e.g. with the help of NAMFIS.<ref>{{Cite journal |last=Wieske |first=Lianne H. E. |last2=Peintner |first2=Stefan |last3=Erdélyi |first3=Máté |date=July 2023 |title=Ensemble determination by NMR data deconvolution |url=https://www.nature.com/articles/s41570-023-00494-x |journal=Nature Reviews Chemistry |language=en |volume=7 |issue=7 |pages=511–524 |doi=10.1038/s41570-023-00494-x |issn=2397-3358|url-access=subscription }}</ref>