Editing Propranolol (section)

== Interactions ==

Since beta blockers are known to relax the cardiac muscle and constrict the smooth muscle, beta-adrenergic antagonists, including propranolol, have an additive effect with other drugs that decrease blood pressure or decrease cardiac contractility or conductivity. Clinically significant interactions particularly occur with:<ref name="Rossi" />
* [[Verapamil]]
* [[Epinephrine]] (adrenaline)
* [[Beta2-adrenergic receptor agonist|β<sub>2</sub>-adrenergic receptor agonists]]
** [[Salbutamol]] (albuterol), [[levosalbutamol]], [[formoterol]], [[salmeterol]], [[clenbuterol]], others
* [[Clonidine]]
* [[Ergot alkaloid]]s
* [[Isoprenaline]] (isoproterenol)
* [[Nonsteroidal anti-inflammatory drug]]s (NSAIDs)
* [[Quinidine]]
* [[Cimetidine]]
* [[Lidocaine]]
* [[Phenobarbital]]
* [[Rifampicin]]
* [[Fluvoxamine]] (slows down the metabolism of propranolol significantly, leading to increased blood levels of propranolol)<ref>{{cite journal | vauthors = van Harten J | title = Overview of the pharmacokinetics of fluvoxamine | journal = Clinical Pharmacokinetics | volume = 29 | issue = Suppl 1 | pages = 1–9 | year = 1995 | pmid = 8846617 | doi = 10.2165/00003088-199500291-00003 | s2cid = 71812133 }}</ref>