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SIDS
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===Other=== A 2022 study found that infants who died of SIDS exhibited significantly lower specific activity of [[butyrylcholinesterase]], an enzyme involved in the brain's arousal pathway, shortly after birth. This can serve as a [[Biomarker (medicine)|biomarker]] to identify infants with a potential [[Autonomic nervous system|autonomic]] [[cholinergic]] dysfunction and elevated risk for SIDS.<ref>{{cite journal | vauthors = Harrington CT, Hafid NA, Waters KA | title = Butyrylcholinesterase is a potential biomarker for Sudden Infant Death Syndrome | journal = eBioMedicine | volume = 80 | pages = 104041 | date = June 2022 | pmid = 35533499 | pmc = 9092508 | doi = 10.1016/j.ebiom.2022.104041 | s2cid = 248645079 }}</ref><ref>{{Cite web |title=Researchers Pinpoint Reason Infants Die From SIDS |url=https://www.biospace.com/article/researchers-answer-how-and-why-infants-die-from-sids/ |access-date=2022-05-12 |website=BioSpace |language=en-US |archive-date=10 May 2022 |archive-url=https://web.archive.org/web/20220510182628/https://www.biospace.com/article/researchers-answer-how-and-why-infants-die-from-sids/ |url-status=live }}</ref><ref>{{cite news |title=Groundbreaking New Study Finds Possible Explanation for SIDS |url=https://www.goodnewsnetwork.org/groundbreaking-new-study-finds-possible-explanation-for-sids/ |agency=Goods News Network |publisher=Goods News Network |date=May 17, 2022 |access-date=20 May 2022 |archive-date=22 May 2022 |archive-url=https://web.archive.org/web/20220522123206/https://www.goodnewsnetwork.org/groundbreaking-new-study-finds-possible-explanation-for-sids/ |url-status=live }}</ref> SIDS has been linked to cold weather, with this association believed to be due to over-bundling and thus, overheating.<ref>{{cite web |title=NIH alerts caregivers to increase in SIDS risk during cold weather |url=https://www.nih.gov/news-events/news-releases/nih-alerts-caregivers-increase-sids-risk-during-cold-weather |website=National Institutes of Health (NIH) |access-date=27 July 2018 |language=en |date=3 September 2015 |archive-date=10 April 2019 |archive-url=https://web.archive.org/web/20190410154310/https://www.nih.gov/news-events/news-releases/nih-alerts-caregivers-increase-sids-risk-during-cold-weather |url-status=live }}</ref> Premature babies are at four times the risk of SIDS, possibly related to an underdeveloped ability to automatically control the cardiovascular system.<ref>{{cite journal | vauthors = Horne RS | title = Effects of prematurity on heart rate control: implications for sudden infant death syndrome | journal = Expert Review of Cardiovascular Therapy | volume = 4 | issue = 3 | pages = 335β343 | date = May 2006 | pmid = 16716094 | doi = 10.1586/14779072.4.3.335 | s2cid = 26689292 }}</ref> A 2-part edition of ''[[The Cook Report]]'' from 1994 claimed that antimony- and phosphorus-containing compounds used as fire retardants in [[PVC]] and other cot mattress materials were a cause of SIDS. Subsequent investigation by an Expert Panel led by Lady Limerick found that there was no evidence to support this claim.<ref>See [https://web.archive.org/web/20001026033455/http://www.sids.org.uk/fsid/limerick.htm FSID Press release].</ref> The report also states that toxic gas cannot be generated from antimony in mattresses and that babies had SIDS on mattresses that did not contain the compound. It has been suggested that some cases of SIDS may be related to ''[[Staphylococcus aureus]]'' and ''[[Escherichia coli]]'' infections.<ref>{{cite journal | vauthors = Weber MA, Klein NJ, Hartley JC, Lock PE, Malone M, Sebire NJ | title = Infection and sudden unexpected death in infancy: a systematic retrospective case review | journal = Lancet | volume = 371 | issue = 9627 | pages = 1848β1853 | date = May 2008 | pmid = 18514728 | doi = 10.1016/S0140-6736(08)60798-9 | s2cid = 8017934 }}</ref>
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