Editing Serotonin transporter (section)

== Neuroimaging ==
The distribution of the serotonin transporter in the [[brain]] may be imaged with [[positron emission tomography]] using [[radioligand]]s called [[3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile|DASB]] and DAPP; the first such studies on the human brain were reported in 2000.<ref name="pmid11105830">{{cite journal | vauthors = Houle S, Ginovart N, Hussey D, Meyer JH, Wilson AA | title = Imaging the serotonin transporter with positron emission tomography: initial human studies with [11C]DAPP and [11C]DASB | journal = European Journal of Nuclear Medicine | volume = 27 | issue = 11 | pages = 1719–1722 | date = November 2000 | pmid = 11105830 | doi = 10.1007/s002590000365 | s2cid = 18932686 }}</ref> DASB and DAPP are not the only radioligands for the serotonin transporter.  There are numerous others, with the most popular probably being the [[β-CIT]] radioligand with an [[isotopes of iodine|iodine-123]] [[isotope]] that is used for brain scanning with ''[[single-photon emission computed tomography]]'' (SPECT) according to a 1993 article in the ''Journal of Neural Transmission''.<ref name="pmid8110440">{{cite journal | vauthors = Brücke T, Kornhuber J, Angelberger P, Asenbaum S, Frassine H, Podreka I | title = SPECT imaging of dopamine and serotonin transporters with [123I]beta-CIT. Binding kinetics in the human brain | journal = Journal of Neural Transmission. General Section | volume = 94 | issue = 2 | pages = 137–146 | year = 1993 | pmid = 8110440 | doi = 10.1007/BF01245007 | s2cid = 22034290 }}</ref> The radioligands were used in 2006 to examine whether variables such as age, gender or [[genotype]] are associated with differential serotonin transporter binding.<ref>{{Cite journal | vauthors = Brust P, Hesse S, Muller U, Szabo Z | title = Neuroimaging of the Serotonin Transporter &mdash; Possibilities and Pitfalls | journal = Current Psychiatry Reviews | date = February 2006 | volume = 2 | issue = 1 | pages = 111&ndash;149 | url = http://www-bmu.psychiatry.cam.ac.uk/publications/brust06neu.pdf | doi = 10.2174/157340006775101508 | url-status = dead | archive-url = https://web.archive.org/web/20110723033800/http://www-bmu.psychiatry.cam.ac.uk/publications/brust06neu.pdf | archive-date = 23 July 2011 | df = dmy-all }}</ref> Healthy subjects that have a high score of [[neuroticism]]&mdash;a [[Trait theory|personality trait]] in the [[Revised NEO Personality Inventory]]&mdash;were found to have more serotonin transporter binding in the [[thalamus]] in 2007.<ref name="pmid17336939">{{cite journal | vauthors = Takano A, Arakawa R, Hayashi M, Takahashi H, Ito H, Suhara T | title = Relationship between neuroticism personality trait and serotonin transporter binding | journal = Biological Psychiatry | volume = 62 | issue = 6 | pages = 588–592 | date = September 2007 | pmid = 17336939 | doi = 10.1016/j.biopsych.2006.11.007 | s2cid = 41664835 }}</ref>