Editing Spindle checkpoint (section)

===Meiosis===

In mouse [[oocytes]], [[DNA damage (naturally occurring)|DNA damage]] induces [[meiosis|meiotic prophase I]] arrest that is mediated by the spindle assembly checkpoint.<ref name = Collins2015>{{cite journal |vauthors=Collins JK, Lane SI, Merriman JA, Jones KT |title=DNA damage induces a meiotic arrest in mouse oocytes mediated by the spindle assembly checkpoint |journal=Nat Commun |volume=6 |issue= |pages=8553 |date=November 2015 |pmid=26522232 |pmc=4659839 |doi=10.1038/ncomms9553 |bibcode=2015NatCo...6.8553C }}</ref>  Arrested oocytes do not enter the subsequent stage, anaphase I.  DNA double strand breaks, UVB and ionizing radiation induced DNA damage cause an effective block to anaphase promoting complex activity.<ref name = Collins2015/>  This checkpoint may help prevent oocytes with damaged DNA from progressing to become fertilizable mature eggs.<ref name = Collins2015/>  During prophase arrest mouse oocytes appear to use both [[homologous recombination|homologous recombinational repair]] and  [[non-homologous end joining]] to repair DNA double-strand breaks.<ref>{{cite journal |vauthors=Lee C, Leem J, Oh JS |title=Selective utilization of non-homologous end-joining and homologous recombination for DNA repair during meiotic maturation in mouse oocytes |journal=Cell Prolif |volume=56 |issue=4 |pages=e13384 |date=April 2023 |pmid=36564861 |pmc=10068936 |doi=10.1111/cpr.13384 }}</ref>