Editing Structural genomics (section)

===''Mycobacterium tuberculosis'' proteome===
The goal of the [[Mycobacterium Tuberculosis Structural Genomics Consortium|TB Structural Genomics Consortium]] is to determine the structures of potential drug targets in ''[[Mycobacterium tuberculosis]]'', the bacterium that causes tuberculosis. The development of novel drug therapies against tuberculosis are particularly important given the growing problem of [[multi-drug-resistant tuberculosis]].

The fully sequenced genome of ''M. tuberculosis'' has allowed scientists to clone many of these protein targets into expression vectors for purification and structure determination by X-ray crystallography.  Studies have identified a number of target proteins for structure determination, including extracellular proteins that may be involved in pathogenesis, iron-regulatory proteins, current drug targets, and proteins predicted to have novel folds. So far, structures have been determined for 708 of the proteins encoded by ''M. tuberculosis''.