Editing XanGo (section)

===Effectiveness===

In February 2006, the U.C. Berkeley Wellness Newsletter, sponsored by the [[University of California at Berkeley]], said that "Mangosteen marketers make farfetched and unsubstantiated claims for their products." The newsletter notes that "there are no clinical trials, and what happens in a test tube or animal may not occur in a human. Any reported benefits in humans have been anecdotal. No one even knows if the processed fruit juice and capsules retain the potentially beneficial compounds. What’s more, the juice is typically a mix of fruit juices&nbsp;– with an undisclosed amount of mangosteen in it."<ref>[http://www.wellnessletter.com/html/wl/2006/wlAskExperts0206.html "Ask the Experts"], U.C. Berkeley Wellness Newsletter, February 2006.</ref>

[[Ralph W. Moss (writer)|Ralph Moss]], an [[alternative cancer treatment]] advocate,<ref>[http://www.cancerdecisions.com/about.html Ralph W. Moss, PhD], Author Biography, The Moss Reports</ref> has said of mangosteen juice:
{{quote|In my opinion, what we have here is simply an overpriced fruit drink. Fruit drinks are often healthful beverages. But the only reason I can see that the promoters of mangosteen can get away with charging $37 for this product is that they are playing on patients' hopes and fears in a cynical way. Without the health claims, open or implied, the product could only be sold for at most $5 or $6 (which, for example, is the cost of antioxidant-rich pomegranate juice).<ref>{{Citation
 |author=Ralph W. Moss |publication-date=May 16, 2004 |title=Cancer Decisions |at=A Friendly Skeptic Looks at Mangosteen, Part II |periodical=The Moss Reports |publisher=CancerDecisions.com |url=http://www.cancerdecisions.com/051604.html |archive-url=https://web.archive.org/web/20040603013421/http://cancerdecisions.com/051604.html |archive-date=June 3, 2004 }}</ref>}}

A 2008 medical [[case report]] described a patient with severe [[acidosis]] possibly attributable to a year of daily use (to lose weight, dose not described) of mangosteen juice (brand not described) infused with [[xanthonoid]]s,<ref>{{cite journal |author=Wong LP, Klemmer PJ |title=Severe lactic acidosis associated with juice of the mangosteen fruit Garcinia mangostana |journal=American Journal of Kidney Diseases |volume=51 |issue=5 |pages=829–33 |date=May 2008 |pmid=18436094 |doi=10.1053/j.ajkd.2007.12.043}}</ref> as occurs in the manufacture of Xango juice. The authors proposed that chronic exposure to alpha-[[mangostin]], a xanthone, could be toxic to [[mitochondria]]l function,<ref>{{cite journal  |vauthors=Matsumoto K, Akao Y, Yi H, etal |title=Preferential target is mitochondria in alpha-mangostin-induced apoptosis in human leukemia HL60 cells |journal=Bioorganic & Medicinal Chemistry |volume=12 |issue=22 |pages=5799–806 |date=November 2004 |pmid=15498656 |doi=10.1016/j.bmc.2004.08.034}}</ref> leading to impairment of [[cellular respiration]] and production of [[lactic acidosis]].