Editing Cingulate cortex (section)

=== Depression ===
The cingulate gyrus is heavily implicated in [[Major depressive disorder|depressive disorders]]. The subgenual region, which lies below the genu of the [[corpus callosum]], is especially important.<ref name=":0" /> This site is the target of [[Deep brain stimulation|deep-brain stimulation therapy]] for depression, an invasive therapy used when all other treatment methods have failed.<ref name=":0">{{Cite book |last=Martin |first=John H. |title=Neuroanatomy: text and atlas |date=2021 |publisher=McGraw Hill |isbn=978-1-259-64249-4 |edition=5th |location=New York |chapter=Chapter 16: The Limbic System and Cerebral Circuits for Reward, Emotions, and Memory}}</ref>

Isolated [[stroke]] of the cingulate gyrus has also been found to induce depression, potentially implicating this region in [[post-stroke depression]] which may occur following stroke of a larger part of the brain.<ref>{{Cite journal |last1=Ribeiro |first1=Nuno Filipe |last2=Madruga |first2=Luís |date=May 2021 |title=A sudden and severe depressive episode after a left cingulate gyrus stroke: a case report of post-stroke depression and review of literature |url=https://pubmed.ncbi.nlm.nih.gov/33825944 |journal=Journal of Neural Transmission (Vienna, Austria: 1996) |volume=128 |issue=5 |pages=711–716 |doi=10.1007/s00702-021-02334-y |issn=1435-1463 |pmid=33825944}}</ref>