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==== Synesthesia ==== {{main|Synesthesia}} In certain forms of [[synesthesia]], perceiving letters and numbers ([[grapheme–color synesthesia]]) or hearing sounds ([[chromesthesia]]) will evoke a perception of color. Behavioral and [[functional neuroimaging]] experiments have demonstrated that these color experiences lead to changes in behavioral tasks and lead to increased activation of brain regions involved in color perception, thus demonstrating their reality, and similarity to real color percepts, albeit evoked through a non-standard route. Synesthesia can occur genetically, with 4% of the population having variants associated with the condition. Synesthesia has also been known to occur with brain damage, drugs, and sensory deprivation.<ref>{{cite journal|last1=Brang|first1=David|title=Survival of the Synesthesia Gene: Why Do People Hear Colors and Taste Words?|journal=PLOS Biology|date=22 November 2011|volume=9|issue=11|pages=e1001205|doi=10.1371/journal.pbio.1001205|pmid=22131906|pmc=3222625|doi-access=free}}</ref> The philosopher Pythagoras experienced synesthesia and provided one of the first written accounts of the condition in approximately 550 BCE. He created mathematical equations for musical notes that could form part of a scale, such as an octave.<ref>{{cite web|title=A Brief History of Synesthesia in the Arts|url=http://www.daysyn.com/history.html|access-date=9 February 2022}}</ref>
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