Editing DNA microarray (section)

=== Annotation ===
The relation between a probe and the [[mRNA]] that it is expected to detect is not trivial.<ref>{{cite journal|last1=Barbosa-Morais|first1=N. L.|last2=Dunning|first2=M. J.|last3=Samarajiwa|first3=S. A.|last4=Darot|first4=J. F. J.|last5=Ritchie|first5=M. E.|last6=Lynch|first6=A. G.|last7=Tavare|first7=S.|title=A re-annotation pipeline for Illumina BeadArrays: improving the interpretation of gene expression data|journal=Nucleic Acids Research|date=18 November 2009|volume=38|issue=3|pages=e17|doi=10.1093/nar/gkp942|pmid=19923232|pmc=2817484}}</ref> Some mRNAs may cross-hybridize probes in the array that are supposed to detect another mRNA. In addition, mRNAs may experience amplification bias that is sequence or molecule-specific. Thirdly, probes that are designed to detect the mRNA of a particular gene may be relying on genomic [[Expressed sequence tag|EST]] information that is incorrectly associated with that gene.