Open main menu
Home
Random
Recent changes
Special pages
Community portal
Preferences
About Wikipedia
Disclaimers
Incubator escapee wiki
Search
User menu
Talk
Dark mode
Contributions
Create account
Log in
Editing
Depersonalization
(section)
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
== Treatment == Currently, no universally accepted treatment guidelines have been established for depersonalization. Pharmacotherapy remains a primary avenue of treatment, with medications such as [[clomipramine]], [[fluoxetine]], [[lamotrigine]], and [[opioid antagonist]]s being commonly prescribed. However, it is important to note that none of these medications have demonstrated a potent anti-dissociative effect in managing symptoms.<ref name="Simeon-2004" /> In addition to pharmacological interventions, various psychotherapeutic techniques have been employed in attempts to alleviate depersonalization symptoms. Modalities such as [[Therapy|trauma-focused therapy]] and [[Cognitive behavioral therapy|cognitive-behavioral techniques]] have been utilized, although their efficacy remains uncertain and not firmly established.<ref name="Simeon-2004" />[[File:Depersonalization Disorder by Boris D. Ogñenovich.png|thumb|An attempt at a visual representation of depersonalization]] Treatment is dependent on the underlying cause, whether it is organic or psychological in origin. If depersonalization is a symptom of neurological disease, then diagnosis and treatment of the specific disease is the first approach. Depersonalization can be a cognitive symptom of such diseases as [[amyotrophic lateral sclerosis]], [[Alzheimer's disease]], [[multiple sclerosis]] (MS), or any other neurological disease affecting the brain.<ref>{{cite web |title=Overview of Child Neglect and Abuse – Overview of Child Neglect and Abuse |url=https://www.msdmanuals.com/home/children-s-health-issues/child-neglect-and-abuse/overview-of-child-neglect-and-abuse |website=MSD Manual Consumer Version |access-date=28 June 2024 |language=en}}</ref><ref>{{cite journal |last1=Murphy |first1=RJ |title=Depersonalization/Derealization Disorder and Neural Correlates of Trauma-related Pathology: A Critical Review. |journal=Innovations in Clinical Neuroscience |date=January 2023 |volume=20 |issue=1–3 |pages=53–59 |pmid=37122581 |pmc=10132272}}</ref> For those with both depersonalization and [[migraine]], [[tricyclic antidepressant]]s are often prescribed. If depersonalization is a symptom of psychological causes such as developmental trauma, treatment depends on the diagnosis. In case of [[dissociative identity disorder]] or DD-NOS as a developmental disorder, in which extreme developmental [[Psychological trauma|trauma]] interferes with formation of a single cohesive identity, treatment requires proper psychotherapy, and—in the case of additional (co-morbid) disorders such as [[eating disorders]]—a team of specialists treating such an individual. It can also be a symptom of [[borderline personality disorder]], which can be treated in the long term with proper psychotherapy and psychopharmacology.<ref name="pmid16960469">{{cite journal |doi=10.1097/01.WNF.0000228368.17970.DA |pmid=16960469 |title=Lamotrigine as an Add-on Treatment for Depersonalization Disorder |journal=[[Clinical Neuropharmacology]] |volume=29 |issue=5 |pages=253–258 |year=2006 |last1=Sierra |first1=Mauricio |last2=Baker |first2=Dawn |last3=Medford |first3=Nicholas |last4=Lawrence |first4=Emma |last5=Patel |first5=Maxine |last6=Phillips |first6=Mary L. |last7=David |first7=Anthony S. |s2cid=38595510}}</ref> The treatment of chronic depersonalization is considered in [[depersonalization disorder]]. A 2001 Russian study showed that [[naloxone]], a drug used to reverse the intoxicating effects of opioid drugs, can successfully treat depersonalization disorder. According to the study: "In three of 14 patients, depersonalization symptoms disappeared entirely and seven patients showed a marked improvement. The therapeutic effect of naloxone provides evidence for the role of the endogenous opioid system in the pathogenesis of depersonalization."<ref name="pmid11448093">{{cite journal |doi=10.1177/026988110101500205 |pmid=11448093 |title=Effect of naloxone therapy on depersonalization: A pilot study |journal=[[Journal of Psychopharmacology]] |volume=15 |issue=2 |pages=93–95 |year=2001 |last1=Nuller |first1=Yuri L. |last2=Morozova |first2=Marina G. |last3=Kushnir |first3=Olga N. |last4=Hamper |first4=Nikita |s2cid=22934937 }}</ref> The anticonvulsant drug [[lamotrigine]] has shown some success in treating symptoms of depersonalization, often in combination with a [[selective serotonin reuptake inhibitor]] and is the first drug of choice at the depersonalisation research unit at King's College London.<ref name="pmid16960469"/><ref>{{cite journal |doi=10.1186/2050-7283-1-20 |pmid=25566370 |pmc=4269982 |title=Evidence-based treatment for Depersonalisation-derealisation Disorder (DPRD) |journal=BMC Psychology |volume=1 |issue=1 |pages=20 |year=2013 |last1=Somer |first1=Eli |last2=Amos-Williams |first2=Taryn |last3=Stein |first3=Dan J. |doi-access=free }}</ref><ref>{{cite journal |doi=10.1192/apt.11.2.92 |title=Understanding and treating depersonalisation disorder |journal=[[Advances in Psychiatric Treatment]] |volume=11 |issue=2 |pages=92–100 |year=2005 |last1=Medford |first1=Nick |last2=Sierra |first2=Mauricio |last3=Baker |first3=Dawn |last4=David |first4=Anthony S. |doi-access=free}}</ref>
Edit summary
(Briefly describe your changes)
By publishing changes, you agree to the
Terms of Use
, and you irrevocably agree to release your contribution under the
CC BY-SA 4.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)