Editing Dimerization (section)

=== G protein-coupled receptors ===
As the largest and most diverse family of [[Receptor (biochemistry)|receptors]] within the human genome, [[G protein-coupled receptor]]s (GPCR) have been studied extensively, with recent studies supporting their ability to form dimers.<ref>{{Citation |last1=Faron-Górecka |first1=Agata |title=Chapter 10 - Understanding GPCR dimerization |date=2019-01-01 |url=https://www.sciencedirect.com/science/article/pii/S0091679X18301080 |journal=Methods in Cell Biology |volume=149 |pages=155–178 |editor-last=Shukla |editor-first=Arun K. |series=G Protein-Coupled Receptors, Part B |publisher=Academic Press |language=en |doi=10.1016/bs.mcb.2018.08.005 |access-date=2022-10-27 |last2=Szlachta |first2=Marta |last3=Kolasa |first3=Magdalena |last4=Solich |first4=Joanna |last5=Górecki |first5=Andrzej |last6=Kuśmider |first6=Maciej |last7=Żurawek |first7=Dariusz |last8=Dziedzicka-Wasylewska |first8=Marta|pmid=30616817 |isbn=9780128151075 |s2cid=58577416 |url-access=subscription }}</ref> GPCR dimers include both homodimers and heterodimers formed from related members of the GPCR family.<ref>{{Cite journal |last1=Rios |first1=C. D. |last2=Jordan |first2=B. A. |last3=Gomes |first3=I. |last4=Devi |first4=L. A. |date=2001-11-01 |title=G-protein-coupled receptor dimerization: modulation of receptor function |url=https://www.sciencedirect.com/science/article/pii/S0163725801001607 |journal=Pharmacology & Therapeutics |language=en |volume=92 |issue=2 |pages=71–87 |doi=10.1016/S0163-7258(01)00160-7 |pmid=11916530 |issn=0163-7258|url-access=subscription }}</ref> While not all, some GPCRs require dimerization to function, such as [[GABAB receptor|GABA<sub>B</sub>]]-receptor, emphasizing the importance of dimers in biological systems.<ref>{{Cite journal |last=Lohse |first=Martin J |date=2010-02-01 |title=Dimerization in GPCR mobility and signaling |url=https://www.sciencedirect.com/science/article/pii/S1471489209001672 |journal=Current Opinion in Pharmacology |series=GPCR |language=en |volume=10 |issue=1 |pages=53–58 |doi=10.1016/j.coph.2009.10.007 |pmid=19910252 |issn=1471-4892|url-access=subscription }}</ref>[[File:Receptor_Tyrosine_Kinase_Dimerization.jpg|thumb|335x335px|class=skin-invert-image|Receptor tyrosine kinase dimerization]]