Editing Extracellular matrix (section)

===Extracellular vesicles===
In 2016, Huleihel et al., reported the presence of DNA, RNA, and Matrix-bound nanovesicles (MBVs) within ECM bioscaffolds.<ref name="Huleihel e1600502">{{cite journal | vauthors = Huleihel L, Hussey GS, Naranjo JD, Zhang L, Dziki JL, Turner NJ, Stolz DB, Badylak SF | title = Matrix-bound nanovesicles within ECM bioscaffolds | journal = Science Advances | volume = 2 | issue = 6 | pages = e1600502 | date = June 2016 | pmid = 27386584 | pmc = 4928894 | doi = 10.1126/sciadv.1600502 | bibcode = 2016SciA....2E0502H }}</ref> MBVs shape and size were found to be consistent with previously described [[Exosome (vesicle)|exosomes]]. MBVs cargo includes different protein molecules, lipids, DNA, fragments, and miRNAs. Similar to ECM bioscaffolds, MBVs can modify the activation state of macrophages and alter different cellular properties such as; proliferation, migration and cell cycle. MBVs are now believed to be an integral and functional key component of ECM bioscaffolds.{{cn|date=April 2025}}