Editing Gene duplication (section)

===Loss===
Often the resulting genomic variation leads to gene dosage dependent neurological disorders such as [[Rett syndrome|Rett-like syndrome]] and [[Pelizaeus–Merzbacher disease]].<ref>{{cite journal | vauthors = Lee JA, Lupski JR | title = Genomic rearrangements and gene copy-number alterations as a cause of nervous system disorders | journal = Neuron | volume = 52 | issue = 1 | pages = 103–21 | date = October 2006 | pmid = 17015230 | doi = 10.1016/j.neuron.2006.09.027 | s2cid = 22412305 | doi-access = free }}</ref>  Such detrimental mutations are likely to be lost from the population and will not be preserved or develop novel functions. However, many duplications are, in fact, not detrimental or beneficial, and these neutral sequences may be lost or may spread through the population through random fluctuations via [[genetic drift]].