Editing Interactome (section)

===Protein function prediction===
Protein interaction networks have been used to predict the function of proteins of unknown functions.<ref name="Schwikowski2000">{{Cite journal | last1 = Schwikowski | first1 = B. | last2 = Uetz | first2 = P. | last3 = Fields | first3 = S. | title = A network of protein–protein interactions in yeast | journal = Nature Biotechnology | volume = 18 | issue = 12 | pages = 1257–1261 | year = 2000 | doi = 10.1038/82360 | pmid = 11101803 | s2cid = 3009359 }}</ref><ref name="McDermottJ2005">{{cite journal |doi=10.1093/bioinformatics/bti514 |vauthors=McDermott J, Bumgarner RE, Samudrala R |title=Functional annotation from predicted protein interaction networks|journal=Bioinformatics|volume=21 |issue=15|pages=3217–3226|year=2005|pmid=15919725|doi-access=free}}</ref> This is usually based on the assumption that uncharacterized proteins have similar functions as their interacting proteins (''guilt by association''). For example, YbeB, a protein of unknown function was found to interact with ribosomal proteins and later shown to be involved in bacterial and eukaryotic (but not archaeal) [[translation (biology)|translation]].<ref name="YbeB">{{Cite journal | last1 = Rajagopala | first1 = S. V. | last2 = Sikorski | first2 = P. | last3 = Caufield | first3 = J. H. | last4 = Tovchigrechko | first4 = A. | last5 = Uetz | first5 = P. | title = Studying protein complexes by the yeast two-hybrid system | doi = 10.1016/j.ymeth.2012.07.015 | journal = Methods | volume = 58 | issue = 4 | pages = 392–399 | year = 2012 | pmid = 22841565 | pmc =3517932 }}</ref> Although such predictions may be based on single interactions, usually several interactions are found. Thus, the whole network of interactions can be used to predict protein functions, given that certain functions are usually enriched among the interactors.<ref name="Schwikowski2000"/> The term ''hypothome'' has been used to denote an interactome wherein at least one of the genes or proteins is a [[hypothetical protein]].<ref>{{cite journal |vauthors=Desler C, Zambach S, Suravajhala P, Rasmussen LJ |title=Introducing the hypothome: a way to integrate predicted proteins in interactomes |journal=International Journal of Bioinformatics Research and Applications |volume=10 |issue=6 |pages=647–52 |year=2014 |pmid=25335568 |doi=10.1504/IJBRA.2014.065247 }}</ref>