Editing Paradoxical reaction (section)

==Causes==
[[Image:GABAa receptor.gif|thumb|350px|GABA<sub>A</sub> receptor with its five subunits and where various ligands bind.]]
The mechanism of a paradoxical reaction has as yet (2019) not been fully clarified, in no small part due to the fact that signal transfer of single [[neuron]]s in [[subcortical]] areas of the human brain is usually not accessible.{{citation needed|date=June 2024}}

There are, however, multiple indications that paradoxical reactions upon – for example – benzodiazepines, barbiturates, [[inhalational anesthetic]]s, [[propofol]], [[neurosteroid]]s, and [[Alcohol (drug)|alcohol]] are associated with structural deviations of [[GABAA receptor|GABA<sub>A</sub> receptor]]s. The combination of the five subunits of the receptor (see image) can be altered in such a way that for example, the receptor's response to GABA remains unchanged but the response to one of the named substances is dramatically different from the normal one.{{citation needed|date=June 2024}}
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