Editing Plasmodium falciparum (section)

=====Schizont=====
At the schizont stage, the parasite replicates its DNA multiple times and multiple mitotic divisions occur asynchronously.<ref>{{cite journal | last1 = Read | first1 = M. | last2 = Sherwin | first2 = T. | last3 = Holloway | first3 = S. P. | last4 = Gull | first4 = K. | last5 = Hyde | first5 = J. E. | year = 1993 | title = Microtubular organization visualized by immunofluorescence microscopy during erythrocytic schizogony in ''Plasmodium falciparum'' and investigation of post-translational modifications of parasite tubulin | journal = Parasitology | volume = 106 | issue = 3| pages = 223–232 | doi=10.1017/s0031182000075041| pmid = 8488059 | s2cid = 24655319 }}</ref><ref>{{cite journal |last1=Arnot |first1=David E. |last2=Ronander |first2=Elena |last3=Bengtsson |first3=Dominique C. |title=The progression of the intra-erythrocytic cell cycle of ''Plasmodium falciparum'' and the role of the centriolar plaques in asynchronous mitotic division during schizogony |journal=International Journal for Parasitology |date=January 2011 |volume=41 |issue=1 |pages=71–80 |doi=10.1016/j.ijpara.2010.07.012 |pmid = 20816844 }}</ref> Cell division and multiplication in the erythrocyte is called erythrocytic schizogony. Each schizont forms 16-18 merozoites.<ref name="1.5"/> The red blood cells are ruptured by the merozoites. The liberated merozoites invade fresh erythrocytes. A free merozoite is in the bloodstream for roughly 60 seconds before it enters another erythrocyte.<ref name=cowman/>

The duration of one complete erythrocytic schizogony is approximately 48 hours. This gives rise to the characteristic clinical manifestations of falciparum malaria, such as fever and chills, corresponding to the synchronous rupture of the infected erythrocytes.<ref name=trampuz03>{{cite journal|last1=Trampuz|first1=Andrej|last2=Jereb|first2=Matjaz|last3=Muzlovic|first3=Igor|last4=Prabhu|first4=Rajesh M|title=Clinical review: Severe malaria|journal=Critical Care|date=2003|volume=7|issue=4|pages=315–23|doi=10.1186/cc2183|pmid=12930555|pmc=270697 |doi-access=free }}</ref>