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Platelet
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=====GPIIb/IIIa activation===== Collagen-mediated GPVI signalling increases the platelet production of [[thromboxane A2]] (TXA2) and decreases the production of [[prostacyclin]]. This occurs by altering the metabolic flux of platelet's [[eicosanoid]] synthesis pathway, which involves enzymes [[phospholipase A2]], [[PTGS1|cyclo-oxygenase 1]], and [[thromboxane-A synthase]]. Platelets secrete thromboxane A2, which acts on the platelet's own [[thromboxane receptor]]s on the platelet surface (hence the so-called "out-in" mechanism), and those of other platelets. These receptors trigger intraplatelet signaling, which converts [[GPIIb/IIIa]] receptors to their active form to initiate ''aggregation''.<ref name="pmid16036569"/>
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