Editing Primary biliary cholangitis (section)

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[[Elafibranor]] (Iqirvo) was approved for medical use as a second-line/alternative therapy for primary biliary cholangitis in the United States in June 2024.<ref>{{cite press release |title=Ipsen's Iqirvo receives U.S. FDA accelerated approval as a first-in-class PPAR treatment for primary biliary cholangitis |date=10 June 2024 |url=https://www.ipsen.com/press-releases/ipsens-iqirvo-receives-u-s-fda-accelerated-approval-as-a-first-in-class-ppar-treatment-for-primary-biliary-cholangitis/ |access-date=11 June 2024 |website=Ipsen}}</ref> Elafibranor is a [[peroxisome proliferator-activated receptor]] (PPAR) agonist, and while the mechanism of action is not fully understood, it is thought to reduce [[bile acid]] synthesis by downregulating [[CYP7A1]] activity dependent on [[fibroblast growth factor 21]] (FGF21).<ref name=":3" />

[[Seladelpar]] (Livdelzi) was approved for medical use as a second-line/alternative therapy for primary biliary cholangitis in the United States in August 2024.<ref>{{cite press release |title=Gilead's Livdelzi (Seladelpar) Granted Accelerated Approval for Primary Biliary Cholangitis by U.S. FDA |date=14 August 2024 |publisher=Gilead |url=https://www.businesswire.com/news/home/20240814469557/en/Gilead%E2%80%99s-Livdelzi-Seladelpar-Granted-Accelerated-Approval-for-Primary-Biliary-Cholangitis-by-U.S.-FDA |via=Business Wire |access-date=15 August 2024}}</ref> Like elafibranor, seladelpar is a PPAR agonist that reduces bile acid synthesis by downregulating FGF21-mediated CYP7A1 activity.<ref name=":4" />

Additional medications are being investigated as potential treatments for PBC, and found to be ineffective as single agents (monotherapy), including: [[chlorambucil]], [[colchicine]], [[cyclosporine]], [[corticosteroids]], [[azathioprine]], [[malotilate]], methotrexate, [[mycophenolate mofetil]], [[penicillamine]], and [[thalidomide]].<ref name="AASLD_2018" /> [[Budesonide]] is sometimes used as an off-label treatment for PBC, although its efficacy is controversial.<ref name="AASLD_2018" /> [[Seladelpar]], a [[PPAR-delta]] receptor agonist, is being studied for treatment of PBC.<ref>{{cite journal |last1=Hirschfield |first1=Gideon M. |last2=Shiffman |first2=Mitchell L. |last3=Gulamhusein |first3=Aliya |last4=Kowdley |first4=Kris V. |last5=Vierling |first5=John M. |last6=Levy |first6=Cynthia |last7=Kremer |first7=Andreas E. |last8=Zigmond |first8=Ehud |last9=Andreone |first9=Pietro |last10=Gordon |first10=Stuart C. |last11=Bowlus |first11=Christopher L. |last12=Lawitz |first12=Eric J. |last13=Aspinall |first13=Richard J. |last14=Pratt |first14=Daniel S. |last15=Raikhelson |first15=Karina |last16=Gonzalez-Huezo |first16=Maria S. |last17=Heneghan |first17=Michael A. |last18=Jeong |first18=Sook-Hyang |last19=Ladrón de Guevara |first19=Alma L. |last20=Mayo |first20=Marlyn J. |last21=Dalekos |first21=George N. |last22=Drenth |first22=Joost P.H. |last23=Janczewska |first23=Ewa |last24=Leggett |first24=Barbara A. |last25=Nevens |first25=Frederik |last26=Vargas |first26=Victor |last27=Zuckerman |first27=Eli |last28=Corpechot |first28=Christophe |last29=Fassio |first29=Eduardo |last30=Hinrichsen |first30=Holger |last31=Invernizzi |first31=Pietro |last32=Trivedi |first32=Palak J. |last33=Forman |first33=Lisa |last34=Jones |first34=David E.J. |last35=Ryder |first35=Stephen D. |last36=Swain |first36=Mark G. |last37=Steinberg |first37=Alexandra |last38=Boudes |first38=Pol F. |last39=Choi |first39=Yun-Jung |last40=McWherter |first40=Charles A. |title=Seladelpar efficacy and safety at 3 months in patients with primary biliary cholangitis: ENHANCE, a phase 3, randomized, placebo-controlled study |journal=Hepatology |date=6 April 2023 |volume=78 |issue=2 |pages=397–415 |doi=10.1097/HEP.0000000000000395|pmid=37386786 |pmc=10344437 |hdl=11380/1319587 |hdl-access=free }}</ref><ref>{{cite journal |last1=Hasegawa |first1=Sho |last2=Yoneda |first2=Masato |last3=Kurita |first3=Yusuke |last4=Nogami |first4=Asako |last5=Honda |first5=Yasushi |last6=Hosono |first6=Kunihiro |last7=Nakajima |first7=Atsushi |title=Cholestatic Liver Disease: Current Treatment Strategies and New Therapeutic Agents |journal=Drugs |date=1 July 2021 |volume=81 |issue=10 |pages=1181–1192 |doi=10.1007/s40265-021-01545-7 |issn=1179-1950|doi-access=free |pmid=34142342 |pmc=8282588 }}</ref>