Editing Prochlorococcus (section)

== Metabolism ==
Most [[Cyanobacteria|cyanobacterium]] are known to have an incomplete [[tricarboxylic acid cycle]] (TCA).<ref>{{Cite journal |last1=García-Fernández |first1=Jose M. |last2=Diez |first2=Jesús |date=December 2004 |title=Adaptive mechanisms of nitrogen and carbon assimilatory pathways in the marine cyanobacteria ''Prochlorococcus'' |journal=Research in Microbiology |volume=155 |issue=10 |pages=795–802 |doi=10.1016/j.resmic.2004.06.009 |pmid=15567272 |issn=0923-2508|doi-access=free }}</ref><ref name="Zhang-2011">{{Cite journal |last1=Zhang |first1=Shuyi |last2=Bryant |first2=Donald A. |date=2011-12-16 |title=The Tricarboxylic Acid Cycle in Cyanobacteria |url=https://www.science.org/doi/10.1126/science.1210858 |journal=Science |language=en |volume=334 |issue=6062 |pages=1551–3 |doi=10.1126/science.1210858 |pmid=22174252 |bibcode=2011Sci...334.1551Z |s2cid=206536295 |issn=0036-8075|url-access=subscription }}</ref> In this process, [[2-oxoglutarate decarboxylase]] (2OGDC) and [[succinic semialdehyde dehydrogenase]] (SSADH), replace the enzyme [[2-oxoglutarate dehydrogenase]] (2-OGDH).<ref name="Zhang-2011" /> Normally, when this enzyme complex joins with [[NADP+]], it can be converted to succinate from [[2-Oxoglutarate|2-oxoglutarate]] (2-OG).<ref name="Zhang-2011" /> This pathway is non-functional in ''Prochlorococcus'',<ref name="Zhang-2011" /> as [[succinate dehydrogenase]] has been lost evolutionarily to conserve energy that may have otherwise been lost to phosphate metabolism.<ref>{{Cite journal |last1=Casey |first1=John R. |last2=Mardinoglu |first2=Adil |last3=Nielsen |first3=Jens |last4=Karl |first4=David M. |date=2016-12-27 |editor-last=Gutierrez |editor-first=Marcelino |title=Adaptive Evolution of Phosphorus Metabolism in ''Prochlorococcus'' |journal=mSystems |language=en |volume=1 |issue=6 |pages=e00065–16 |doi=10.1128/mSystems.00065-16 |issn=2379-5077 |pmc=5111396 |pmid=27868089}}</ref>