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Prostate
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===Inflammation=== {{Main|Prostatitis}} <!--Introduction, symptoms and investigations--> [[File:Inflammation of prostate.jpg|thumb|[[Micrograph]] showing [[inflammation|inflamed]] prostate ([[H&E stain]]) with large amount of darker cells ([[leukocyte]]s); area without inflammation seen on the left]] Prostatitis is [[inflammation]] of the prostate gland. It can be caused by infection with bacteria, or other noninfective causes. Inflammation of the prostate can cause [[painful urination]] or ejaculation, groin pain, difficulty passing urine, or [[constitutional symptoms]] such as [[fever]] or [[malaise|tiredness]].{{sfn|Davidson's|2018|pp=437β9}} When inflamed, the prostate becomes enlarged and is tender when touched during [[digital rectal examination]]. The bacteria responsible for the infection may be detected by a [[urine culture]].{{sfn|Davidson's|2018|pp=437β9}} <!--Treatment--> Acute prostatitis and chronic bacterial prostatitis are treated with [[antibiotic]]s.{{sfn|Davidson's|2018|pp=437β9}} [[chronic prostatitis/chronic pelvic pain syndrome|Chronic non-bacterial prostatitis, or male chronic pelvic pain syndrome]] is treated by a large variety of modalities including the medications [[alpha blockers]], [[non-steroidal anti-inflammatories]] and [[amitriptyline]],{{sfn|Davidson's|2018|pp=437β9}} [[antihistamine]]s, and other [[anxiolytic]]s.<ref name="Anderson-2006" /> Other treatments that are not medications may include [[physical therapy]],<ref>{{Cite web |year=2014 |title=Physical Therapy Treatment for Prostatitis/chronic pelvic pain syndrome |url=http://www.chronicprostatitis.com/the-wise-anderson-protocol/ |access-date=2014-10-22}}</ref> [[psychotherapy]], [[neuromodulation|nerve modulator]]s, and [[surgery]]. More recently, a combination of [[trigger point]] and psychological therapy has proved effective for category III prostatitis as well.<ref name="Anderson-2006">{{Cite journal |vauthors=Anderson RU, Wise D, Sawyer T, Chan CA |year=2006 |title=Sexual dysfunction in men with chronic prostatitis/chronic pelvic pain syndrome: improvement after trigger point release and paradoxical relaxation training |journal=J. Urol. |volume=176 |issue=4 Pt 1 |pages=1534β8; discussion 1538β9 |citeseerx=10.1.1.383.7495 |doi=10.1016/j.juro.2006.06.010 |pmid=16952676}}</ref>
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