Editing Protein complex (section)

===Evolutionary significance of multiprotein complex assembly===
In homomultimeric complexes, the [[homomeric]] proteins assemble in a way that mimics evolution. That is, an intermediate in the assembly process is present in the complex's evolutionary history.<ref>{{cite journal|last1=Levy|first1=Emmanuel D|last2=Boeri Erba|first2=Elisabetta|last3=Robinson|first3=Carol V|last4=Teichmann|first4=Sarah A|title=Assembly reflects evolution of protein complexes|journal=Nature|date=July 2008|volume=453|issue=7199|pages=1262–5|doi=10.1038/nature06942|pmid=18563089|pmc=2658002|bibcode=2008Natur.453.1262L}}</ref>
The opposite phenomenon is observed in heteromultimeric complexes, where gene fusion occurs in a manner that preserves the original assembly pathway.<ref name = "pmid23582331"/>