Editing Repeated sequence (DNA) (section)

=== Spinocerebellar ataxias ===
The disease [[spinocerebellar ataxia]]s has CAG [[Trinucleotide repeat disorder|trinucleotide repeat sequences that underlie several types of spinocerebellar ataxias]] (SCAs-[[Spinocerebellar ataxia type 1|SCA1]]; [[Spinocerebellar ataxia|SCA2; SCA3; SCA6; SCA7; SCA12; SCA17]]).<ref name="Abugable2019">{{cite journal | vauthors = Abugable AA, Morris JL, Palminha NM, Zaksauskaite R, Ray S, El-Khamisy SF | title = DNA repair and neurological disease: From molecular understanding to the development of diagnostics and model organisms | journal = DNA Repair | volume = 81 | pages = 102669 | date = September 2019 | pmid = 31331820 | doi = 10.1016/j.dnarep.2019.102669 | doi-access = free }}</ref> Similar to Huntington's disease, the polyglutamine tail created due to this trinucleotide expansion causes aggregation of proteins, preventing normal cellular function and causing neurodegeneration.<ref>{{cite journal | vauthors = Honti V, Vécsei L | title = Genetic and molecular aspects of spinocerebellar ataxias | journal = Neuropsychiatric Disease and Treatment | volume = 1 | issue = 2 | pages = 125–133 | date = June 2005 | pmid = 18568057 | pmc = 2413192 | doi = 10.2147/nedt.1.2.125.61044 | doi-access = free }}</ref>