Editing Reperfusion injury (section)

=== Cannabinoids ===
A study published in 2012 show that the [[Synthetic cannabinoids|synthetic]] analogue of the [[Cannabinoid|phytocannabinoid]] [[Tetrahydrocannabivarin]] (THCV), Δ<sup>8</sup>-Tetrahydrocannabivarin (Δ<sup>8</sup>-THCV) and its [[metabolite]] 11-OH-Δ<sup>8</sup>-THCV, prevent [[Liver|hepatic]] [[Ischemia|ischaemia]]/reperfusion injury by decreasing [[oxidative stress]] and [[Inflammation|inflammatory]] responses through cannabinoid [[Cannabinoid receptor type 2|CB2 receptors]] and thereby decrease tissue injury and inflammation with a protective effect against liver damage. Pretreatment with a CB2 [[receptor antagonist]] attenuated the protective effects of Δ<sup>8</sup>-THCV, while a [[Cannabinoid receptor type 1|CB1]] [[Cannabinoid receptor antagonist|antagonist]] tended to enhance it.<ref>{{cite journal |last1=Bátkai |first1=Sándor |last2=Mukhopadhyay |first2=Partha |last3=Horváth |first3=Bėla |last4=Rajesh |first4=Mohanraj |last5=Gao |first5=Rachel Y |last6=Mahadevan |first6=Anu |last7=Amere |first7=Mukkanti |last8=Battista |first8=Natalia |last9=Lichtman |first9=Aron H |last10=Gauson |first10=Lisa A |last11=Maccarrone |first11=Mauro |last12=Pertwee |first12=Roger G |last13=Pacher |first13=Pál |title=Δ8-Tetrahydrocannabivarin prevents hepatic ischaemia/reperfusion injury by decreasing oxidative stress and inflammatory responses through cannabinoid CB2 receptors: Δ8-Tetrahydrocannabivarin for reperfusion injury |journal=British Journal of Pharmacology |date=April 2012 |volume=165 |issue=8 |pages=2450–2461 |doi=10.1111/j.1476-5381.2011.01410.x |pmid=21470208 |pmc=3423240 }}</ref>

An earlier study published in 2011 found, that [[Cannabidiol]] (CBD) also protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response of oxidative and [[Nitrate|nitrative]] stress, and thereby [[cell death]] and [[Tissue (biology)|tissue]] injury, but independent from classical CB1 and CB2 receptors.<ref>{{cite journal |last1=Mukhopadhyay |first1=Partha |last2=Rajesh |first2=Mohanraj |last3=Horváth |first3=Béla |last4=Bátkai |first4=Sándor |last5=Park |first5=Ogyi |last6=Tanchian |first6=Galin |last7=Gao |first7=Rachel Y. |last8=Patel |first8=Vivek |last9=Wink |first9=David A. |last10=Liaudet |first10=Lucas |last11=Haskó |first11=György |last12=Mechoulam |first12=Raphael |last13=Pacher |first13=Pál |title=Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death |journal=Free Radical Biology and Medicine |date=May 2011 |volume=50 |issue=10 |pages=1368–1381 |doi=10.1016/j.freeradbiomed.2011.02.021 |pmid=21362471 |pmc=3081988 }}</ref>