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Reverse transcription polymerase chain reaction
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=== Genetic disease diagnosis === RT-PCR can be used to diagnose [[genetic disease]] such as [[Lesch–Nyhan syndrome]]. This genetic disease is caused by a malfunction in the [[HPRT1]] gene, which clinically leads to the fatal [[urinary stone|uric acid urinary stone]] and symptoms similar to [[gout]].{{clarify|text=[6]|date=April 2020}} Analyzing a pregnant mother and a [[fetus]] for mRNA expression levels of HPRT1 will reveal if the mother is a carrier and if the fetus will likely to develop Lesch–Nyhan syndrome.<ref name="pmid23046577">{{cite journal |vauthors=Torres RJ, Garcia MG, Puig JG | title = Carrier and prenatal diagnosis of Lesch-Nyhan disease due to a defect in HPRT gene expression regulation | journal = Gene | volume = 511 | issue = 2 | pages = 306–7 |date=December 2012 | pmid = 23046577 | doi = 10.1016/j.gene.2012.09.121 }}</ref>
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