Editing Angiosarcoma (section)

== Causes ==
Angiosarcoma develops when damage to the [[DNA]] of [[Endothelium|endothelial cells]] causes them to [[Cell proliferation|divide uncontrollably]] and prevents [[Programmed cell death|programmed death]]. This allows them to grow into a [[Neoplasm|mass]] invading other parts of the body and consuming its resources. If part of the mass breaks off and enters the [[Circulatory system|circulatory]] or [[lymphatic system]] (which is very common due to angiosarcomas arising from the [[Endothelium|lining]] of said systems) it allows them to lodge elsewhere in the body. This process is called [[metastasis]] and is a negative prognostic factor.<ref>{{Cite web|date=2007-09-17|title=What Is Cancer? - National Cancer Institute|url=https://www.cancer.gov/about-cancer/understanding/what-is-cancer|access-date=2021-08-09|website=www.cancer.gov|language=en}}</ref> The underlying causes of DNA damage is not understood but several risk factors are widely accepted.{{citation needed|date=October 2021}}

Accepted risk factors include [[lymphedema]], [[radiation therapy]], [[neurofibromatosis]], [[Maffucci syndrome]], [[Klippel–Trénaunay syndrome|Klippel-Trenaunay syndrome]]<ref name="Angiosarcoma" /> and chemicals such as [[arsenic]], [[thorotrast]] and [[vinyl chloride]].<ref name="cancer.gov" />

A 2020 study analyzing the [[genome]] of cutaneous angiosarcomas suggests that [[Ultraviolet|ultraviolet radiation]] may be a [[Carcinogen|causative agent]] of angiosarcomas.<ref name="project">{{Cite journal|last1=Painter|first1=Corrie A.|last2=Jain|first2=Esha|last3=Tomson|first3=Brett N.|last4=Dunphy|first4=Michael|last5=Stoddard|first5=Rachel E.|last6=Thomas|first6=Beena S.|last7=Damon|first7=Alyssa L.|last8=Shah|first8=Shahrayz|last9=Kim|first9=Dewey|last10=Gómez Tejeda Zañudo|first10=Jorge|last11=Hornick|first11=Jason L.|date=February 2020|title=The Angiosarcoma Project: enabling genomic and clinical discoveries in a rare cancer through patient-partnered research|url=https://pubmed.ncbi.nlm.nih.gov/32042194/|journal=Nature Medicine|volume=26|issue=2|pages=181–187|doi=10.1038/s41591-019-0749-z|issn=1546-170X|pmid=32042194|s2cid=211074464}}</ref>

[[Immunosuppression]] may play a role in the [[pathogenesis]] of angiosarcoma. There have been reports of angiosarcoma in [[Immunosuppression|immunosuppressed]] individuals following [[kidney transplantation]]. The association between lymphedema and angiosarcoma may be due to localized [[immunodeficiency]], however this [[hypothesis]] has not been confirmed. Some studies suggest a link between [[HIV/AIDS|AIDS]] and angiosarcoma though this may be due to [[Medical error|misdiagnosed]] [[Kaposi's sarcoma]].<ref name="Angiosarcoma" />