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Anterior cingulate cortex
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===Schizophrenia spectrum disorders=== In individuals with [[schizophrenia]] spectrum disorders, the anterior cingulate cortex has been found to be smaller compared to that of control subjects.<ref name="Haznedar 2004">{{Cite journal | last1 = Haznedar | first1 = M. M. | last2 = Buchsbaum | first2 = M. S. | last3 = Hazlett | first3 = E. A. | last4 = Shihabuddin | first4 = L. | last5 = New | first5 = A. | last6 = Siever | first6 = L. J. | doi = 10.1016/j.schres.2004.02.025 | title = Cingulate gyrus volume and metabolism in the schizophrenia spectrum | journal = Schizophrenia Research | volume = 71 | issue = 2β3 | pages = 249β262 | year = 2004 | pmid = 15474896| s2cid = 28889346 }}</ref><ref name="Fujiwara 2007">{{Cite journal | last1 = Fujiwara | first1 = H. | last2 = Hirao | first2 = K. | last3 = Namiki | first3 = C. | last4 = Yamada | first4 = M. | last5 = Shimizu | first5 = M. | last6 = Fukuyama | first6 = H. | last7 = Hayashi | first7 = T. | last8 = Murai | first8 = T. | doi = 10.1016/j.neuroimage.2007.03.068 | title = Anterior cingulate pathology and social cognition in schizophrenia: A study of gray matter, white matter and sulcal morphometry | journal = NeuroImage | volume = 36 | issue = 4 | pages = 1236β1245 | year = 2007 | pmid = 17524666| url = https://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/124279/3/yigak03320.pdf | hdl = 2433/124279 | s2cid = 25750603 | hdl-access = free }}</ref> [[Meta-analyses]] have shown that its activity is reduced during emotion processing,<ref>{{cite journal |last1= Taylor |first1=S-F |last2= Kang |first2=J |last3= Brege |first3=I-S |last4= Tso |first4=I-F | last5= Hosanagar |first5=A | last6= Johnson |first6=T | title= Meta-analysis of functional neuroimaging studies of emotion perception and experience in schizophrenia |journal=Biological Psychiatry |date=15 Jan 2012 |volume=71| issue=2| pages=136-145| doi=10.1016/j.biopsych.2011.09.007|pmid= 21993193}}</ref> and its [[functional connectivity]] with the [[striatum]] is diminished at rest, which has been linked to cognitive rigidity.<ref>{{cite journal |last1= Grimaldi |first1=D-A |last2= Patane' |first2=A |last3= Cattarinussi |first3=G |last4= Sambataro |first4=F |title= Functional connectivity of the striatum in psychosis: Meta-analysis of functional magnetic resonance imaging studies and replication on an independent sample |journal=Neuroscience & Biobehavioral Reviews |date=2 May 2025 |volume=174 |doi=10.1016/j.neubiorev.2025.106179 |pmid= 40288705}}</ref>
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