Editing Doctor Octopus (section)

===''All-New, All-Different Marvel''===
As part of the ''[[All-New, All-Different Marvel]]'' event, Otto Octavius is still dead but a copy of his consciousness is shown to be inside the Living Brain where he is still in love with Anna Maria Marconi.<ref>''The Amazing Spider-Man'' (vol. 4) #1. Marvel Comics.</ref> Following the events of ''Spider-Verse'', Otto Octavius had backed up his consciousness in one of his gauntlets (the Superior Spider-Man's web-shooters) that slept for 100 days using the technology he acquired from 2099.<ref name="Amazing Spider-Man #18" /><ref>''The Superior Spider-Man'' #32-33. Marvel Comics.</ref> The gauntlet housed a copy of Octavius's consciousness up to the point of ''Spider-Verse'' (without the memories of learning about power and responsibility for his act of self-sacrifice in ''Goblin Nation'', as this copy would remain asleep during this time). After transforming the gauntlet into a version of an Octobot, he backed himself up in the Living Brain while waiting for the next opportunity to take over Parker's body again, planning to act at a time when Parker's spider-sense would be taxed so that he would miss the relevant signals.<ref name="Amazing Spider-Man #18">''The Amazing Spider-Man'' (vol. 4) #18. Marvel Comics.</ref>

At the time when the Living Brain was at Parker Industries' London branch, Doctor Octopus' consciousness expresses anger over being forced to act like their lackey. After Sajani Jaffrey is fired by Peter Parker for conspiring against him, Doctor Octopus' consciousness smirks as Anna is made the head of Parker Industries' London branch.<ref>''The Amazing Spider-Man'' (vol. 4) #5. Marvel Comics.</ref>

===="Dead No More: The Clone Conspiracy"====
During the "[[Dead No More: The Clone Conspiracy]]" storyline, Peter decides to have Parker Industries get familiar with New U Enterprises' "New U" system, which is a program where replacement organs are cloned for those suffering from serious injuries. Upon hearing about it from within the Living Brain, Doctor Octopus' consciousness expresses an interest in the procedure.<ref>''The Amazing Spider-Man'' (vol. 4) #16. Marvel Comics.</ref> When Peter Parker scanned the Living Brain to find out why it was acting unusually, Doctor Octopus' consciousness asked why it was erased. Realizing the truth, Peter Parker shut down the Living Brain, only for Doctor Octopus' consciousness to reactivate it and cause it to self-destruct while escaping in the Octobot. Arriving at New U Enterprises, the Doctor Octopus-possessed Octobot plans to get his biological body back, convinced that the consciousness in Parker's body was "infected" by its time in Spider-Man to believe that Peter was superior rather than himself.<ref name="Amazing Spider-Man #18"/> Upon heading to Potter's Field, the Doctor Octopus-possessed Octobot finds that Doctor Octopus' body was grave-robbed, alongside those of Alistair Alphonso Smythe and other villains. It traces the grave robbery to New U Technologies. Finding Doctor Octopus' body, the Doctor Octopus-possessed Octobot allowed it to be cloned and perfected. After eliminating the copy of Peter Parker's consciousness, Doctor Octopus gains control of the clone body and emerges from the vat where he resembles his earlier appearance. The [[Ben Reilly|Jackal]] was present where he presents him with his tentacle pack. Now an ally of Jackal, Doctor Octopus receives the special New U Pills to prevent his body from suffering clone degeneration.<ref name="Amazing Spider-Man #20">''The Amazing Spider-Man'' (vol. 4) #20. Marvel Comics.</ref>

When Spider-Man later infiltrates New U Technologies after witnessing video footage of one of its subjects suffering from cellular degeneration, he evades the initial security force, including the Rhino and [[Electro (Francine Frye)|Electro]]. When he discovers what appears to be [[Gwen Stacy]], he is distracted long enough to be caught off-guard by the reborn Octavius, once again in his own body with new tentacles.<ref>''The Clone Conspiracy'' #1. Marvel Comics.</ref> With Spider-Man trapped in his tentacles, Doctor Octopus tells him that he is not a clone or a hologram, but the real Otto Octavius.<ref name="Amazing Spider-Man #20"/>

After Silk escapes from New U Technologies, Doctor Octopus attacks Spectro who was unable to phase through the walls with the test subject. Doctor Octopus and Spectro fight until Electro arrives and knocks out Spectro. Doctor Octopus later experiments with Spectro and plans to put him into a cloned body.<ref>''Silk'' (vol. 2) #15. Marvel Comics.</ref>

While studying the clones of [[Kaine Parker|Kaine]] and Electro to perfect the Proto-Clone, Anna Maria was brought to Otto and she becomes uncomfortable when Doctor Octopus starts appealing towards his love interest. When Jackal enters the laboratory, Anna Maria reveals she knows how to stop the decaying process on the clones and Jackal offers her the "Proto-Clone" body in exchange for the formula. Octavius takes offense to Jackal's comments on Maria's dwarfism and attacks his boss. Then he pulls a switch which activates the Carrion Virus in all of the clones and causes them to start rapidly decaying.<ref>''The Clone Conspiracy'' #4. Marvel Comics.</ref>

Doctor Octopus fights Jackal to allow Peter and Anna Maria the time to transmit the frequency, Spider-Man correctly anticipating that Octavius would act to protect Anna regardless of their own history. The frequency has a huge effect on Doctor Octopus and Jackal. Upon checking New U Technologies' Haven following the broadcast, Spider-Man and Anna Maria find that [[Ben Reilly]], Doctor Octopus, and Gwen Stacy have been seemingly reduced to dust.<ref>''The Clone Conspiracy'' #5. Marvel Comics.</ref> It was later revealed that Doctor Octopus rendered Ben unconscious and escaped by transmitting his mind into the Proto-Clone (a perfect clone of Peter Parker) before Ben could.<ref>''The Amazing Spider-Man'' (vol. 4) #24. Marvel Comics.</ref>