Editing Functional genomics (section)

====STARR-seq====
{{Main|STARR-seq}}
STARR-seq is a technique similar to MPRAs to assay enhancer activity of randomly sheared genomic fragments. In the original publication,<ref>{{cite journal | vauthors = Arnold CD, Gerlach D, Stelzer C, Boryń ŁM, Rath M, Stark A | title = Genome-wide quantitative enhancer activity maps identified by STARR-seq | journal = Science | volume = 339 | issue = 6123 | pages = 1074–7 | date = March 2013 | pmid = 23328393 | doi = 10.1126/science.1232542 | bibcode = 2013Sci...339.1074A | s2cid = 54488955 }}</ref> randomly sheared fragments of the ''Drosophila'' genome were placed downstream of a minimal promoter. Candidate enhancers amongst the randomly sheared fragments will transcribe themselves using the minimal promoter. By using sequencing as a readout and controlling for input amounts of each sequence the strength of putative enhancers are assayed by this method.