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HIV vaccine development
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===Approaches to destroying or damaging the virion or its parts (Stage I-VII)=== Here, "damage" means inhibiting or stopping the ability of virion to process any of the ''Phase II-VII''. Here are the different classification of methods: * By nature of method: ** Physical methods (''Stage I-VII'') ** Chemical and biological methods (''Stage I-VII'') * By damaging target of the [[HIV#Structure and genome|HIV virion structure]]:<ref>{{cite journal | vauthors = McGovern SL, Caselli E, Grigorieff N, Shoichet BK | title = A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening | journal = Journal of Medicinal Chemistry | volume = 45 | issue = 8 | pages = 1712β22 | date = April 2002 | pmid = 11931626 | doi = 10.1021/jm010533y }}</ref><ref>Compared with overview in: Fisher, Bruce; Harvey, Richard P.; Champe, Pamela C. (2007). Lippincott's Illustrated Reviews: Microbiology (Lippincott's Illustrated Reviews Series). Hagerstown, MD: Lippincott Williams & Wilkins. {{ISBN|0-7817-8215-5}}. Page 3</ref> ** Damaging the [[Envelope glycoprotein GP120|Docking Glycoprotein gp120]]<ref>{{cite report | title = HIV Sequence Compendium | year = 2017 | vauthors = Foley B, Leitner T, Apetrei C, Hahn B, Mizrachi I, Mullins J, Rambaut A, Wolinsky S, Korber B | publisher = Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, NM, LA-UR 17-25240 }}</ref> (''Stage I-III, VI, VII'') ** Damaging the [[Gp41|Transmembrane Glycoprotein gp41]]<ref>{{cite journal | vauthors = Malashkevich VN, Chan DC, Chutkowski CT, Kim PS | title = Crystal structure of the simian immunodeficiency virus (SIV) gp41 core: conserved helical interactions underlie the broad inhibitory activity of gp41 peptides | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 16 | pages = 9134β9 | date = August 1998 | pmid = 9689046 | pmc = 21304 | doi = 10.1073/pnas.95.16.9134 | bibcode = 1998PNAS...95.9134M | doi-access = free }}</ref> (''Stage I-III, VI, VII'') ** Damaging the virion matrix (''Stage I-III, VI, VII'') ** Damaging the virion Capsid (''Stage I-III, VI, VII'') ** Damaging the Reverse Transcriptase (''Stage I-VII'') ** Damaging the RNA (''Stage I-VII'')
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