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Reverse transcription polymerase chain reaction
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=== Cancer detection === Scientists are working on ways to use RT-PCR in [[cancer]] detection to help improve [[prognosis]], and monitor response to therapy. Circulating [[tumor cell]]s produce unique mRNA transcripts depending on the type of cancer. The goal is to determine which mRNA transcripts serve as the best [[biomarkers]] for a particular cancer cell type and then analyze its expression levels with RT-PCR.<ref name="pmid17525108">{{cite journal |vauthors=Xi L, Nicastri DG, El-Hefnawy T, Hughes SJ, Luketich JD, Godfrey TE | title = Optimal markers for real-time quantitative reverse transcription PCR detection of circulating tumor cells from melanoma, breast, colon, esophageal, head and neck, and lung cancers | journal = Clin. Chem. | volume = 53 | issue = 7 | pages = 1206โ15 |date=July 2007 | pmid = 17525108 | doi = 10.1373/clinchem.2006.081828 | doi-access = free }}</ref> RT-PCR is commonly used in studying the genomes of [[virus]]es whose genomes are composed of RNA, such as [[Influenzavirus A]], [[retrovirus]]es like [[HIV]] and [[SARS-CoV-2]].<ref>{{cite web |title=Coronavirus: il viaggio dei test |url=https://www.iss.it/web/guest/primo-piano/-/asset_publisher/o4oGR9qmvUz9/content/id/5269706 |website=Istituto Superiore di Sanitร }}</ref>
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