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Sarcoma
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===Grade=== Like some other cancers, sarcomas are assigned a [[Grading (tumors)|grade]] (low, intermediate, or high) based on the appearance of the tumor cells under a microscope.<ref name=":6">{{Cite web|url=https://www.cancer.gov/about-cancer/diagnosis-staging/prognosis/tumor-grade-fact-sheet|title=Tumor Grade|date=2013-05-09|website=National Cancer Institute|language=en|access-date=2019-03-21}}</ref> In general, grade refers to how aggressive the cancer is and how likely it is to spread to other parts of the body ("metastasize").<ref name=":6" /> Low-grade sarcomas have a better prognosis than higher-grade sarcomas, and are usually treated surgically, although sometimes radiation therapy or chemotherapy are used.<ref name=":2" /><ref name=":0" /> Intermediate- and high-grade sarcomas are more frequently treated with a combination of surgery, chemotherapy, or radiation therapy.<ref name=Buecker05>{{cite journal |vauthors=Buecker P |title=Sarcoma: A Diagnosis of Patience |journal=ESUN |volume=2 |issue=5 |year=2005 |url=http://sarcomahelp.org/articles/patience.html |access-date=2009-04-15 |archive-date=4 December 2020 |archive-url=https://web.archive.org/web/20201204224156/http://sarcomahelp.org/articles/patience.html |url-status=dead }}</ref> Since high-grade tumors are more likely to undergo metastasis (invasion and spread to locoregional and distant sites), they are treated more aggressively. The recognition that many sarcomas are sensitive to chemotherapy has dramatically improved the survival of patients. For example, in the era before chemotherapy, long-term survival for pediatric patients with localized osteosarcoma was only about 20%, but now has risen to 60β70%.<ref>{{cite journal | vauthors = Longhi A, Errani C, De Paolis M, Mercuri M, Bacci G | title = Primary bone osteosarcoma in the pediatric age: state of the art | journal = Cancer Treatment Reviews | volume = 32 | issue = 6 | pages = 423β436 | date = October 2006 | pmid = 16860938 | doi = 10.1016/j.ctrv.2006.05.005 }}</ref>
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