Editing Subcutaneous administration (section)

===Infusion===
'''Subcutaneous infusion''', also known as '''interstitial infusion''' or '''hypodermoclysis''', is a form of subcutaneous (under the skin) administration of fluids to the body, often [[saline (medicine)|saline]] or glucose solutions.<ref>[http://www.merriam-webster.com/medical/hypodermoclyses "hypodermoclysis"], ''Merriam-Webster's medical dictionary online''. Retrieved July 19, 2009.</ref> It is the infusion counterpart of [[subcutaneous injection]] with a syringe.

Subcutaneous infusion can be used where a slow rate of fluid uptake is required compared to [[intravenous infusion]].  Typically, it is limited to 1 mL per minute, although it is possible to increase this by using two sites simultaneously.  The chief advantages of subcutaneous infusion over intravenous infusion is that it is cheap and can be administered by non-medical personnel with minimal supervision.  It is therefore particularly suitable for home care.  The enzyme [[hyaluronidase]] can be added to the fluid to improve absorption during the infusion.<ref>Menahem Sasson, Pesach Shvartzman, [http://www.aafp.org/afp/20011101/1575.html "Hypodermoclysis: an alternative infusion technique"], ''American Family Physician'', vol. 64, no. 9, pp. 1575-1579 (November 1, 2001).</ref>

Subcutaneous infusion can be speeded up by applying it to multiple sites simultaneously.  The technique was pioneered by [[Evan O'Neill Kane]] in 1900.  Kane was looking for a technique that was as fast as intravenous infusion but not so risky to use on trauma patients in unhygienic conditions in the field.<ref>Edwin M. Hasbrouck, [https://jamanetwork.com/journals/jama/article-abstract/477272 "An improved device for rapid hypodermoclysis"], ''Journal of the American Medical Association'', '''34''', p.&nbsp;1273, 1900.</ref>