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Toothpaste
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====Miscellaneous components==== Agents are added to suppress the tendency of toothpaste to dry into a powder. Included are various sugar alcohols, such as [[glycerol]], [[sorbitol]], or [[xylitol]], or related derivatives, such as [[1,2-propylene glycol]] and [[polyethyleneglycol]].<ref name=Field>Simon Quellen Field "Why There's Antifreeze in Your Toothpaste: The Chemistry of Household Ingredients" 2008, Chicago Review Press. {{ISBN|1-55652-697-0}}</ref> [[Strontium chloride]] or [[potassium nitrate]] is included in some toothpastes to reduce sensitivity. Two systemic meta-analysis reviews reported that [[arginine]], and calcium sodium phosphosilicate β CSPS containing toothpastes are also effective in alleviating dentinal hypersensitivity respectively.<ref>{{cite journal | vauthors = Yang ZY, Wang F, Lu K, Li YH, Zhou Z | title = Arginine-containing desensitizing toothpaste for the treatment of dentin hypersensitivity: a meta-analysis | journal = Clinical, Cosmetic and Investigational Dentistry | volume = 8 | pages = 1β14 | date = 2016-01-07 | pmid = 26793006 | pmc = 4708190 | doi = 10.2147/CCIDE.S95660 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Hu ML, Zheng G, Zhang YD, Yan X, Li XC, Lin H | title = Effect of desensitizing toothpastes on dentine hypersensitivity: A systematic review and meta-analysis | journal = Journal of Dentistry | volume = 75 | pages = 12β21 | date = August 2018 | pmid = 29787782 | doi = 10.1016/j.jdent.2018.05.012 | s2cid = 44141866 }}</ref> Another randomized clinical trial found superior effects when both formulas were combined.<ref>{{cite journal | vauthors = Hall C, Mason S, Cooke J | title = Exploratory randomised controlled clinical study to evaluate the comparative efficacy of two occluding toothpastes β a 5% calcium sodium phosphosilicate toothpaste and an 8% arginine/calcium carbonate toothpaste β for the longer-term relief of dentine hypersensitivity | journal = Journal of Dentistry | volume = 60 | pages = 36β43 | date = May 2017 | pmid = 28219674 | doi = 10.1016/j.jdent.2017.02.009 | doi-access = free }}</ref> Sodium polyphosphate is added to minimize the formation of tartar.{{citation needed|date=February 2018}} Chlorohexidine mouthwash has been popular for its positive effect on controlling plaque and gingivitis,<ref>{{cite journal | vauthors = James P, Worthington HV, Parnell C, Harding M, Lamont T, Cheung A, Whelton H, Riley P | display-authors = 6 | title = Chlorhexidine mouthrinse as an adjunctive treatment for gingival health | journal = The Cochrane Database of Systematic Reviews | volume = 3 | pages = CD008676 | date = March 2017 | issue = 12 | pmid = 28362061 | pmc = 6464488 | doi = 10.1002/14651858.CD008676.pub2 }}</ref> however, a systemic review studied the effects of Chlorhexidine toothpastes and found insufficient evidence to support its use, tooth surface discoloration was observed as a side effect upon using it, which is considered a negative side effect that can affect patients' compliance.<ref>{{cite journal | vauthors = Slot DE, Berchier CE, Addy M, Van der Velden U, Van der Weijden GA | title = The efficacy of chlorhexidine dentifrice or gel on plaque, clinical parameters of gingival inflammation and tooth discoloration: a systematic review | journal = International Journal of Dental Hygiene | volume = 12 | issue = 1 | pages = 25β35 | date = February 2014 | pmid = 24034716 | doi = 10.1111/idh.12050 }}</ref> [[Sodium hydroxide]], also known as lye or caustic soda, is listed as an inactive ingredient in some toothpaste, for example Colgate Total.
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