Editing Transdifferentiation (section)

===Transition from mouse to human cells===

Generally transdifferentiation that occurs in mouse cells does not translate in effectiveness or speediness in human cells. Pang et al. found that while transcription factors [[ASCL1|Ascl1]], [[Brn2]] and [[Myt1l]] turned mouse cells into mature neurons, the same set of factors only turned human cells into immature neurons. However, the addition of [[NeuroD1]] was able to increase efficiency and help cells reach maturity.<ref>{{Cite journal 
| last1 = Pang | first1 = Z. P. 
| last2 = Yang | first2 = N. 
| last3 = Vierbuchen | first3 = T. 
| last4 = Ostermeier | first4 = A. 
| last5 = Fuentes | first5 = D. R. 
| last6 = Yang | first6 = T. Q. 
| last7 = Citri | first7 = A. 
| last8 = Sebastiano | first8 = V. 
| last9 = Marro | first9 = S. 
| last10 = Südhof 
| doi = 10.1038/nature10202 | first10 = T. C. 
| last11 = Wernig | first11 = M. 
| title = Induction of human neuronal cells by defined transcription factors 
| journal = Nature 
| volume = 476 
| issue = 7359 
| pages = 220–223 
| year = 2011 
| pmid = 21617644 
| pmc =3159048 
| bibcode = 2011Natur.476..220P 
}}</ref>