Editing Vesicular monoamine transporter (section)

===C-terminus and VMAT trafficking cycle===
Several motifs involved in the VMAT [[Vesicle trafficking|trafficking cycle]] are believed to be encoded in the C-terminus. A dileucine motif in the C-terminus is required for VMAT2 [[endocytosis]].<ref name= "Fei"/> Studies suggest the acidic residues in the dileucine motif sort VMAT2 away from constitutive secretory vesicles and into the regulated [[secretory pathway]].<ref name= "Fei"/> The hydrophobic residues in the dileucine motif are thought to couple with the acidic residues as a single unit to help sort VMAT2 to large dense course vesicles.<ref name= "Fei"/> Acidic glutamate residues located upstream of the dileucine motif are known to be important for localization of VMAT2 to large dense core vesicles; these residues are also conserved in VMAT1.<ref name= "Fei"/>