Editing Wilms' tumor (section)

==Epidemiology==
Wilms tumor is the most common malignant renal tumor in children.<ref>{{cite journal | vauthors = Sonn G, Shortliffe LM | s2cid = 23599363 | title = Management of Wilms tumor: current standard of care | language = En | journal = Nature Clinical Practice. Urology | volume = 5 | issue = 10 | pages = 551–60 | date = October 2008 | pmid = 18836464 | doi = 10.1038/ncpuro1218 }}</ref> There are a number of rare genetic syndromes that have been linked to an increased risk of developing Wilms Tumor.<ref name="ReferenceA">{{cite journal | vauthors = Kalish JM, Doros L, Helman LJ, Hennekam RC, Kuiper RP, Maas SM, Maher ER, Nichols KE, Plon SE, Porter CC, Rednam S, Schultz KA, States LJ, Tomlinson GE, Zelley K, Druley TE | title = Surveillance Recommendations for Children with Overgrowth Syndromes and Predisposition to Wilms Tumors and Hepatoblastoma | journal = Clinical Cancer Research | volume = 23 | issue = 13 | pages = e115–e122 | date = July 2017 | pmid = 28674120 | pmc = 5538793 | doi = 10.1158/1078-0432.CCR-17-0710 }}</ref> Screening guidelines vary between countries; however health care professionals are recommending regular ultrasound screening for people with associated genetic syndromes.<ref name="ReferenceA"/>

Wilms' tumor affects approximately one person per 10,000 worldwide before the age of 15 years.<ref name="Epidemiology of Wilms tumor">{{cite journal | vauthors = Breslow N, Olshan A, Beckwith JB, Green DM | title = Epidemiology of Wilms tumor | journal = Medical and Pediatric Oncology | volume = 21 | issue = 3 | pages = 172–81 | date = 1993 | pmid = 7680412 | doi = 10.1002/mpo.2950210305 }}</ref> People of African descent may have slightly higher rates of Wilms' tumor.<ref name="Epidemiology of Wilms tumor"/> The peak age of Wilms' tumor is 3 to 4 years and most cases occur before the age of 10 years.<ref>{{cite journal | vauthors = Breslow NE, Beckwith JB, Perlman EJ, Reeve AE | title = Age distributions, birth weights, nephrogenic rests, and heterogeneity in the pathogenesis of Wilms tumor | journal = Pediatric Blood & Cancer | volume = 47 | issue = 3 | pages = 260–7 | date = September 2006 | pmid = 16700047 | pmc = 1543666 | doi = 10.1002/pbc.20891 }}</ref> A genetic predisposition to Wilms' tumor in individuals with [[aniridia]] has been established, due to deletions in the p13 band on chromosome 11.<ref>{{cite journal | vauthors = Pritchard-Jones K, Fleming S, Davidson D, Bickmore W, Porteous D, Gosden C, Bard J, Buckler A, Pelletier J, Housman D | s2cid = 4350729 | title = The candidate Wilms' tumour gene is involved in genitourinary development | journal = Nature | volume = 346 | issue = 6280 | pages = 194–7 | date = July 1990 | pmid = 2164159 | doi = 10.1038/346194a0 | bibcode = 1990Natur.346..194P }}</ref>