Editing World Community Grid (section)

==Completed subprojects==
===Human Proteome Folding – Phase 1===
{{Main|Human Proteome Folding Project}}

The first project launched on World Community Grid was the Human Proteome Folding Project, or HPF1, which aims to predict the structure of human [[proteins]]. The project was launched on November 16, 2004,<ref name="Completed Research" /> and completed on July 18, 2006.<ref name="Completed Research" /> This project was unique in that computation was done in tandem with the [[grid.org]] distributed computing project.<ref>{{cite web
|url=http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=7683
|title=Launch of Human Proteome Folding Phase 2 project
|author=Viktors
|publisher=World Community Grid
|date=2006-06-26
|access-date=2007-08-04
|archive-date=2019-02-04
|archive-url=https://web.archive.org/web/20190204122437/https://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=7683
|url-status=live
}}</ref> Devised by Richard Bonneau at the [[Institute for Systems Biology]], the project used grid computing to produce the likely structures for each of the proteins using a Rosetta Score. From these predictions, researchers hope to predict the function of the myriad proteins. This increased understanding of the human proteins could prove vital in the search for cures to human [[diseases]].<ref>{{cite web
|url=http://www.worldcommunitygrid.org/projects_showcase/archives/viewHpfResearch.do
|title=Human Proteome Folding Project
|work=Research
|publisher=World Community Grid
|access-date=2007-08-04
|archive-date=2007-08-20
|archive-url=https://web.archive.org/web/20070820042136/http://www.worldcommunitygrid.org/projects_showcase/archives/viewHpfResearch.do
|url-status=live
}}</ref> Computing for this project was officially completed on July 18, 2006.<ref>{{cite web
|url=http://www.worldcommunitygrid.org/projects_showcase/archives/viewHpfOverview.do
|title=Human Proteome Folding Project Overview
|work=Research
|publisher=World Community Grid
|access-date=2007-07-28
|archive-date=2007-07-14
|archive-url=https://web.archive.org/web/20070714022845/http://www.worldcommunitygrid.org/projects_showcase/archives/viewHpfOverview.do
|url-status=live
}}</ref>  Research results for the yeast portion of HPF1 have been published.<ref>{{cite journal | vauthors = Malmström L, Riffle M, Strauss CE, Chivian D, Davis TN, Bonneau R, Baker D | title = Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology | journal = PLOS Biology | volume = 5 | issue = 4 | pages = e76 | date = April 2007 | pmid = 17373854 | pmc = 1828141 | doi = 10.1371/journal.pbio.0050076 | doi-access = free }}</ref>

===Human Proteome Folding – Phase 2===
{{Main|Human Proteome Folding Project}}

'''Human Proteome Folding - Phase 2 (HPF2)''' (launched June 23, 2006<ref name="Active Research" />) was the third project to run on World Community Grid, and completed in 2013. This project, following on from HPF1, focused on human-secreted [[proteins]], with special focus on [[Biomarker (medicine)|biomarkers]] and the proteins on the surface of cells as well as [[Plasmodium]], the organism that causes malaria. HPF2 generates higher-resolution protein models than HPF1. Though these higher-resolution models are more useful, they also require more processing power to generate.<ref>{{cite web
|url=http://www.worldcommunitygrid.org/projects_showcase/viewHpf2Research.do
|title=Human Proteome Folding - Phase 2
|publisher=World Community Grid
|access-date=2007-07-28
|archive-date=2007-08-10
|archive-url=https://web.archive.org/web/20070810070933/http://www.worldcommunitygrid.org/projects_showcase/viewHpf2Research.do
|url-status=live
}}</ref>

In a July 2012 status report, the project scientists reported that the results generated by the WCG calculations are being used by Dr. Markus Landthaler of the Max Delbruch Center for Molecular Medicine (MDC) in Berlin. The HPF2 results helped Dr. Markus Landthaler and his collaborators in writing up a new paper on "The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts"<ref>{{cite journal | vauthors = Baltz AG, Munschauer M, Schwanhäusser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M | display-authors = 6 | title = The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts | journal = Molecular Cell | volume = 46 | issue = 5 | pages = 674–90 | date = June 2012 | pmid = 22681889 | doi = 10.1016/j.molcel.2012.05.021 | doi-access = free }}</ref>

===Help Defeat Cancer===
{{Main|Help Defeat Cancer}}

The Help Defeat Cancer project seeks to improve the ability of medical professionals to determine the best treatment options for patients with breast, head, or neck cancer. The project was launched on July 20, 2006,<ref name="Completed Research" /> and completed in April 2007.<ref name="Completed Research" /> The project worked by identifying visual patterns in large numbers of [[tissue microarray]]s taken from archived tissue samples. By correlating the pattern data with information about treatment and patient outcome, the results of this project could help provide better targeted treatment options.<ref>{{cite web
|url=http://www.worldcommunitygrid.org/projects_showcase/archives/hdc/viewHdcAbout.do
|title=About the Project
|work=Research: Help Defeat Cancer
|publisher=World Community Grid
|access-date=2007-08-04
|archive-date=2007-10-05
|archive-url=https://web.archive.org/web/20071005133324/http://www.worldcommunitygrid.org/projects_showcase/archives/hdc/viewHdcAbout.do
|url-status=live
}}</ref>

===Genome Comparison===
{{Main|Fiocruz Genome Comparison Project}}

The Genome Comparison project is sponsored by the [[Brazil]]ian research institution [[Instituto Oswaldo Cruz|Fiocruz]].<ref name="Active Research" /> The project was launched on November 21, 2006,<ref name="Completed Research" /> and completed on July 21, 2007.<ref name="Completed Research" /> The project seeks to compare gene sequences of different organisms against each other in order to find similarities between them.  Scientists hope to discover what purpose a particular gene sequence serves in a particular function of one organism, via comparing it to a similar gene sequence of known function in another organism.<ref>{{cite web
|url=http://www.worldcommunitygrid.org/projects_showcase/fgc/viewFgcMain.do
|title=Genome Comparison Overview
|work=Research
|publisher=World Community Grid
|access-date=2007-07-28
|archive-date=2007-07-07
|archive-url=https://web.archive.org/web/20070707214605/http://www.worldcommunitygrid.org/projects_showcase/fgc/viewFgcMain.do
|url-status=live
}}</ref>

===Help Cure Muscular Dystrophy – Phase 1===
{{Main|Help Cure Muscular Dystrophy}}

Help Cure Muscular Dystrophy is run by [[Décrypthon]], a collaboration between French Muscular Dystrophy Association, [[CNRS|French National Center for Scientific Research]] and [[IBM]]. Phase 1 was launched on December 19, 2006,<ref name="Active Research" /> and completed on June 11, 2007.<ref name="Help Cure Muscular Dystrophy Phase 1 complete" /> The project investigated [[protein–protein interactions]] for 40,000 proteins whose structures are known, with particular focus on those proteins that play a role in [[neuromuscular diseases]]. The database of information produced will help researchers design molecules to inhibit or enhance binding of particular [[macromolecules]], hopefully leading to better treatments for [[muscular dystrophy]] and other neuromuscular diseases.<ref>{{cite web
|url=http://www.worldcommunitygrid.org/projects_showcase/hcmd/viewHcmdMain.do
|title=Help Cure Muscular Dystrophy
|work=Research
|publisher=World Community Grid
|access-date=2007-07-28
|archive-date=2007-07-01
|archive-url=https://web.archive.org/web/20070701150940/http://www.worldcommunitygrid.org/projects_showcase/hcmd/viewHcmdMain.do
|url-status=live
}}</ref> This project was available only to agents running the [[Grid MP]] client, making it unavailable to users running [[BOINC]].<ref>{{cite web
|url=http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=10647
|title=Launch of the Help Cure Muscular Dystrophy Project
|author=Viktors
|publisher=World Community Grid
|date=2006-12-19
|access-date=2007-07-28
|archive-date=2019-01-30
|archive-url=https://web.archive.org/web/20190130094526/https://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=10647
|url-status=live
}}</ref>

===Discovering Dengue Drugs – Together===
{{Main|Discovering Dengue Drugs – Together}}

Discovering Dengue Drugs – Together was sponsored by scientists at the [[University of Texas]] and the [[University of Chicago]] and will run in two phases.<ref>{{cite web |url=http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=14561#109721 |title=Re: Project about dengue ever |author=Didactylos |publisher=World Community Grid |date=2007-06-21 |access-date=2007-08-07 |archive-date=2022-09-05 |archive-url=https://web.archive.org/web/20220905052735/https://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=14561#109721 |url-status=live }}</ref> Phase 1, launched August 21, 2007,<ref name="Active Research" /> used AutoDock 2007 (the same software used for [[FightAIDS@Home]]) to test potential antiviral drugs (through NS3 [[protease]] inhibition) against viruses from the family [[flaviviridae]] and completed on August 11, 2009.<ref name="DDDTcomplete" /><ref>{{cite web
|url=http://www.worldcommunitygrid.org/projects_showcase/dddt/viewDddtAbout.do
|title=Discovering Dengue Drugs – Together: About the Project
|publisher=World Community Grid
|access-date=2007-08-24
|archive-date=2007-10-05
|archive-url=https://web.archive.org/web/20071005035229/http://www.worldcommunitygrid.org/projects_showcase/dddt/viewDddtAbout.do
|url-status=live
}}</ref> Phase 2 "[uses] a more computationally intensive program to screen the candidates that make it through Phase 1."<ref name="lawrencehardin">{{cite web
|url=http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=15192#114871
|title=Re: Results...
|author=lawrencehardin
|publisher=World Community Grid
|date=2007-07-10
|access-date=2007-08-07
|archive-date=2022-09-05
|archive-url=https://web.archive.org/web/20220905052735/https://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=15192#114871
|url-status=live
}}</ref> The drug candidates that make it through Phase 2 will then be lab-tested.<ref name="lawrencehardin" />

===AfricanClimate@Home===
The mission of AfricanClimate@Home was to develop more accurate climate models of specific regions in Africa. It was intended to serve as a basis for understanding how the climate will change in the future so that measures designed to alleviate the adverse effects of climate change could be implemented. World Community Grid's tremendous computing power was used to understand and reduce the uncertainty with which climate processes were simulated over Africa. Phase 1 of African Climate@Home launched on September 3, 2007,<ref name="AfricanClimate launch">{{cite web|url=http://www.csag.uct.ac.za/worldcommunitygrid|title=AfricanClimate@Home (IBM World Community Grid) Status Page|publisher=[[University of Cape Town]]|access-date=2009-05-08|archive-date=2009-11-06|archive-url=https://web.archive.org/web/20091106150030/http://www.csag.uct.ac.za/worldcommunitygrid|url-status=live}}</ref> and ended in July 2008.<ref name="AfricanClimate SC">{{cite web|url=http://www.worldcommunitygrid.org/projects_showcase/ach/viewAchMain.do|title=AfricanClimate@Home|publisher=World Community Grid|access-date=2009-05-08|archive-date=2009-05-03|archive-url=https://web.archive.org/web/20090503094244/http://www.worldcommunitygrid.org/projects_showcase/ach/viewAchMain.do|url-status=live}}</ref>

===Help Conquer Cancer===
{{Main|Help Conquer Cancer}}

'''Help Conquer Cancer''' project (launched November 1, 2007<ref name="Help Conquer Cancer-WGR" />) is sponsored by the [[Ontario Cancer Institute]] (OCI), Princess Margaret Hospital and University Health Network of Toronto, Canada. The project involves [[X-ray crystallography]]. The mission of Help Conquer Cancer is to improve the results of protein X-ray crystallography, which helps researchers not only annotate unknown parts of the human proteome, but importantly improves their understanding of cancer initiation, progression and treatment.<ref>{{cite web
|url=http://www.worldcommunitygrid.org/projects_showcase/hcc1/viewHcc1Main.do
|title=Help Conquer Cancer research page on WCG
|publisher=Worldcommunitygrid.org
|access-date=2013-05-21
|archive-date=2007-11-16
|archive-url=https://web.archive.org/web/20071116095744/http://www.worldcommunitygrid.org/projects_showcase/hcc1/viewHcc1Main.do
|url-status=live
}}</ref>

The HCC project was the first WCG project benefiting from [[graphics processing unit]]s (GPU)s which helped finish it a lot earlier than initially projected due to the massive power of GPUs. In the April 2013 status report<ref>{{Cite web |url=http://www.cs.utoronto.ca/~juris/WCG/UPDATE-APR2013.pdf |title=Help Conquer Cancer April 2013 Update |access-date=2013-04-11 |archive-date=2013-04-17 |archive-url=https://web.archive.org/web/20130417185421/http://www.cs.utoronto.ca/~juris/WCG/UPDATE-APR2013.pdf |url-status=live }}</ref> the scientists report there is still a lot of data to analyze but that they are preparing a new project that will search for prognostic and predictive signatures (sets of genes, proteins, microRNAs, etc.) that help predict patient survival and response to treatment.
The project finished in May 2013.{{citation needed|date=May 2017}}

===Nutritious Rice for the World===
{{Main|Nutritious Rice for the World}}

The [http://protinfo.compbio.washington.edu/rice Nutritious Rice for the World] project is carried out by [[Ram Samudrala]]'s [http://compbio.washington.edu Computational Biology Research Group] at the [[University of Washington]]. The project was launched on May 12, 2008, and completed on April 6, 2010.<ref name="Nutritious Rice for the World" /> The purpose of this project is to predict the structure of [[protein]]s of major [[strain (biology)|strain]]s of [[rice]], in order to help [[farmer]]s [[plant breeding|breed]] better rice strains with higher [[crop yield]]s, promote greater [[plant disease|disease]] and [[pest (organism)|pest]] resistance, and utilize a full range of [[bioavailability|bioavailable]] [[nutrient]]s that can benefit people around the world, especially in regions where [[malnutrition]] is a critical concern. The project has been covered by more than 200 media outlets since its inception.<ref>{{cite web |url=http://protinfo.compbio.washington.edu/rice/press.html |title=Nutritious Rice for the World |publisher=Protinfo.compbio.washington.edu |access-date=2010-06-07 |archive-date=2010-08-13 |archive-url=https://web.archive.org/web/20100813175034/http://protinfo.compbio.washington.edu/rice/press.html |url-status=live }}</ref>  On April 13, 2010, World Community Grid officially announced that the Nutritious Rice for the World project finished on April 6, 2010.<ref name="Nutritious Rice for the World" />

In April 2014, an update was posted stating that the research team was able to publish structural information about thousands of proteins, and advance the field of computational protein modeling. These results – which were only possible because of the massive amount of donated computing power they had available – are expected to guide future research and plant science efforts.<ref>{{cite web|url=http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=353|title=Live webcast for Nutritious Rice for the World: April 17th, 7:00pm UTC|date=15 April 2014|work=worldcommunitygrid.org|access-date=15 April 2014|archive-date=16 April 2014|archive-url=https://web.archive.org/web/20140416192231/http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=353|url-status=live}}</ref>

===The Clean Energy Project===
{{Main|Clean Energy Project}}

The Clean Energy project is sponsored by the scientists of [[Harvard University]]'s Department of Chemistry and Chemical Biology.<ref name="Worldcommunitygrid.org">{{cite web |url=http://www.worldcommunitygrid.org/projects_showcase/cep1/viewCep1About.do |title=The Clean Energy Project research page on WCG |publisher=Worldcommunitygrid.org |access-date=2010-06-07 |archive-date=2009-04-22 |archive-url=https://web.archive.org/web/20090422051959/http://www.worldcommunitygrid.org/projects_showcase/cep1/viewCep1About.do |url-status=live }}</ref> The mission of the Clean Energy Project is to find new materials for the next generation of [[solar cell]]s and later, [[energy storage]] devices. Researchers are employing [[molecular mechanics]] and [[electronic structure]] calculations to predict the optical and transport properties of molecules that could become the next generation of solar cell materials.{{citation needed|date=May 2017}}

Phase 1 was launched on December 5, 2008, and completed on October 13, 2009.<ref name="CEP Phase 1 complete" />  By harnessing the computing power of the World Community Grid, researchers were able to calculate the electronic properties of tens of thousands of organic materials – many more than could ever be tested in a lab – and determine which candidates are most promising for developing affordable [[solar energy]] technology.<ref>{{cite web |url=http://www.worldcommunitygrid.org/projects_showcase/cep1/viewCep1Main.do |title=The Clean Energy Project research page on WCG |publisher=Worldcommunitygrid.org |access-date=2015-07-15 |archive-date=2009-04-14 |archive-url=https://web.archive.org/web/20090414165742/http://www.worldcommunitygrid.org/projects_showcase/cep1/viewCep1Main.do |url-status=live }}</ref>

Phase 2 was launched June 28, 2010,<ref name="Clean Energy Project-WCG" /> sponsored by the scientists of [[Harvard University]]'s Department of Chemistry and Chemical Biology.<ref name="Worldcommunitygrid.org" /> Further calculations about optical, electronic and other physical properties of the candidate materials are being conducted with the [[Q-Chem]] quantum chemistry software.<ref>[http://www.worldcommunitygrid.org/research/cep2/overview.do The Clean Energy Project - Phase 2] {{Webarchive|url=https://web.archive.org/web/20110717130155/http://www.worldcommunitygrid.org/research/cep2/overview.do |date=2011-07-17 }} "World Community Grid", access-date=2015/7/15</ref> Their findings have been submitted to the [[Energy & Environmental Science]] journal.<ref>{{Cite web|url=https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=519|title=Clean Energy Project Researchers Sharing Results and Planning for the Future|website=www.worldcommunitygrid.org|language=en-US|access-date=2018-03-04|archive-date=2017-07-24|archive-url=https://web.archive.org/web/20170724103810/https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=519|url-status=live}}</ref>

===Help Fight Childhood Cancer===

'''Help Fight Childhood Cancer''' project (launched March 13, 2009<ref name="Help Fight Childhood Cancer-WCG" />) is sponsored by the scientists at [[Chiba Cancer Center Research Institute]] and [[Chiba University]].<ref>{{cite web
|url=http://www.worldcommunitygrid.org/projects_showcase/hfcc/viewHfccAbout.do
|title=Help Fight Childhood Cancer research page on WCG
|publisher=Worldcommunitygrid.org
|date=2009-03-13
|access-date=2010-06-07
|archive-date=2009-04-21
|archive-url=https://web.archive.org/web/20090421073426/http://www.worldcommunitygrid.org/projects_showcase/hfcc/viewHfccAbout.do
|url-status=live
}}</ref> The mission of the Help Fight Childhood Cancer project is to find drugs that can disable three particular proteins associated with [[neuroblastoma]], one of the most frequently occurring [[solid tumors]] in children. Identifying these drugs could potentially make the disease much more curable when combined with [[chemotherapy treatment]].<ref>{{cite web
|url=http://www.worldcommunitygrid.org/projects_showcase/hfcc/viewHfccMain.do
|title=Help Fight Childhood Cancer research page on WCG
|publisher=Worldcommunitygrid.org
|date=2009-03-13
|access-date=2010-06-07
|archive-date=2009-05-03
|archive-url=https://web.archive.org/web/20090503115920/http://www.worldcommunitygrid.org/projects_showcase/hfcc/viewHfccMain.do
|url-status=live
}}</ref>

===Influenza Antiviral Drug Search===
{{Main|Influenza Antiviral Drug Search}}

Influenza Antiviral Drug Search project is sponsored by Dr. Stan Watowich and his research team at [[The University of Texas]] Medical Branch ([[Galveston]], [[Texas]], USA).<ref>{{cite web |url=http://www.worldcommunitygrid.org/projects_showcase/flu1/viewFlu1Part.do |title=Influenza Antiviral Drug Search research page on WCG |publisher=Worldcommunitygrid.org |access-date=2010-06-07 |archive-date=2009-05-30 |archive-url=https://web.archive.org/web/20090530141929/http://www.worldcommunitygrid.org/projects_showcase/flu1/viewFlu1Part.do |url-status=live }}</ref> The project was launched on May 5, 2009, and completed on October 22, 2009.<ref name="flu1complete" /> The mission of the Influenza [[Antiviral drug|Antiviral Drug]] Search project is to find new drugs that can stop the spread of an [[influenza]] infection in the body. The research will specifically address the influenza strains that have become drug resistant as well as new strains that are appearing. Identifying the chemical compounds that are the best candidates will accelerate the efforts to develop treatments that would be useful in managing seasonal influenza outbreaks, and future influenza epidemics and even pandemics.<ref>{{cite web |url=http://www.worldcommunitygrid.org/projects_showcase/flu1/viewFlu1Main.do |title=Influenza Antiviral Drug Search research page on WCG |publisher=Worldcommunitygrid.org |access-date=2010-06-07 |archive-date=2009-05-09 |archive-url=https://web.archive.org/web/20090509074644/http://www.worldcommunitygrid.org/projects_showcase/flu1/viewFlu1Main.do |url-status=live }}</ref> Phase 1 of The Influenza Antiviral Drug Search project has already finished on October 22, 2009. Now the researchers are performing post-processing on the results from Phase 1 and are preparing for Phase 2.<ref name="flu1complete" />

In November 2012, the project's scientists stated that, given the fact that there is no immediate danger of an influenza outbreak, all of the project's results would be posted online and their resources would be refocused on the Dengue Project.<ref>{{cite web|url=http://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,34244|title=Discovering Dengue Drugs – Together project update|publisher=World Community Grid forums|date=2012-11-14|access-date=2014-04-28|archive-date=2015-01-19|archive-url=https://web.archive.org/web/20150119154556/http://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,34244|url-status=live}}</ref>

===Help Cure Muscular Dystrophy – Phase 2===
{{Main|Help Cure Muscular Dystrophy}}

World Community Grid and researchers supported by Decrypthon, a partnership between AFM (French Muscular Dystrophy Association), [[CNRS]] (French National Center for Scientific Research), Universite Pierre et Marie Curie, and IBM were investigating protein–protein interactions for more than 2,200 proteins whose structures are known, with particular focus on those proteins that play a role in [[neuromuscular diseases]]. Phase 2 was launched on May 12, 2009,<ref name="HCMD Phase 2 launch" /> and completed on September 26, 2012. The database of information produced will help researchers design molecules to inhibit or enhance binding of particular [[macromolecules]], hopefully leading to better treatments for [[muscular dystrophy]] and other neuromuscular diseases.<ref>{{cite web
|url=http://www.worldcommunitygrid.org/projects_showcase/hcmd2/viewHcmd2Main.do
|title=Help Cure Muscular Dystrophy Phase 2 research page on WCG
|publisher=Worldcommunitygrid.org
|access-date=2013-05-21
|archive-date=2009-06-02
|archive-url=https://web.archive.org/web/20090602131147/http://www.worldcommunitygrid.org/projects_showcase/hcmd2/viewHcmd2Main.do
|url-status=live
}}</ref>

Phase 2 of the Help Cure Muscular Dystrophy project began once the results from the first phase had been analyzed. Phase 2 ran on the [[BOINC]] platform.<ref name="bbover3" /><ref>{{cite web
|url=http://www.worldcommunitygrid.org/projects_showcase/hcmd/viewHcmdFaq.do
|title=Help Cure Muscular Dystrophy
|work=Research - Project FAQs
|publisher=World Community Grid
|access-date=2013-05-21
|archive-date=2009-07-06
|archive-url=https://web.archive.org/web/20090706212557/http://www.worldcommunitygrid.org/projects_showcase/hcmd/viewHcmdFaq.do
|url-status=live
}}</ref>

===Discovering Dengue Drugs – Together – Phase 2===
{{Main|Discovering Dengue Drugs - Together}}

'''Discovering Dengue Drugs – Together – Phase 2''' (launched February 17, 2010<ref name="Discovering Dengue Drugs - Together-WCG" />) is sponsored by [[The University of Texas Medical Branch]] (UTMB) in [[Galveston]], [[Texas]], United States and the [[University of Chicago]] in [[Illinois]], USA. The mission is to identify promising drug candidates to combat the [[Dengue fever|Dengue]], [[Hepatitis C]], [[West Nile virus|West Nile]], [[Yellow Fever]], and other related viruses. The extensive computing power of World Community Grid will be used to complete the structure-based drug discovery calculations required to identify these drug candidates.<ref>{{cite web
|url=http://www.worldcommunitygrid.org/research/dddt2/overview.do
|title=Discovering Dengue Drugs - Together - Phase 2
|work=Research - Project Overview
|publisher=World Community Grid
|access-date=2013-05-21
|archive-date=2013-04-20
|archive-url=https://web.archive.org/web/20130420064341/http://www.worldcommunitygrid.org/research/dddt2/overview.do
|url-status=live
}}</ref>

===Computing for Clean Water===
'''Computing for Clean Water''' (launched September 20, 2010<ref name="Computing for Clean Water-WCG" /><ref name="Computing for Clean Water-Tsinghua" />) is sponsored by the Center for Nano and Micro Mechanics of [[Tsinghua University]] in [[Beijing]]. The project's mission is to provide deeper insight on the molecular scale into the origins of the efficient flow of water through a novel class of filter materials. This insight will in turn guide future development of low-cost and more efficient water filters. It is estimated that 1.2 billion people lack access to safe drinking water, and 2.6 billion have little or no sanitation. As a result, millions of people die annually – an estimated 3,900 children a day due to a lack of clean water.<ref>{{cite web|url=http://www.worldcommunitygrid.org/research/c4cw/overview.do|title=World Community Grid - Research - Computing for Clean Water|work=worldcommunitygrid.org|access-date=2011-10-27|archive-date=2011-10-30|archive-url=https://web.archive.org/web/20111030022726/http://www.worldcommunitygrid.org/research/c4cw/overview.do|url-status=live}}</ref> On April 25, 2014, the project scientists released an update stating that they had exciting results to report when the paper is submitted and that the project on WCG was finished.<ref>{{cite web|url=http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=355|title=Computing for Clean Water project update|date=25 April 2014|vauthors=Grey F|work=worldcommunitygrid.org|access-date=25 April 2014|archive-date=26 April 2014|archive-url=https://web.archive.org/web/20140426214758/http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=355|url-status=live}}</ref>

===Drug Search for Leishmaniasis===
'''Drug Search for Leishmaniasis''' (launched September 7, 2011<ref name="Drug Search for Leishmaniasis-WCG" />) is spearheaded by the [[University of Antioquia]] in [[Medellín]], [[Colombia]], with assistance from researchers at the University of Texas Medical Branch in Galveston, Texas. The mission is to identify potential molecule candidates that could possibly be developed into treatments for [[Leishmaniasis]]. The extensive computing power of World Community Grid will be used to perform computer simulations of the interactions between millions of chemical compounds and certain target proteins. This will help find the most promising compounds that may lead to effective treatments for the disease.<ref>{{cite web
|url=http://www.worldcommunitygrid.org/research/dsfl/overview.do
|title=Drug Search for Leishmaniasis
|work=Research
|publisher=World Community Grid
|access-date=2011-10-28
|archive-date=2021-07-16
|archive-url=https://web.archive.org/web/20210716010153/https://www.worldcommunitygrid.org/research/dsfl/overview.do
|url-status=live
}}</ref>

===GO Fight Against Malaria Project===
The mission of the '''GO Fight Against Malaria''' project (launched November 16, 2011<ref name="GO Fight Against Malaria Project-WCG" />) is to discover promising drug candidates that could be developed into new drugs that cure drug resistant forms of [[malaria]]. The computing power of World Community Grid will be used to perform computer simulations of the interactions between millions of chemical compounds and certain target proteins, to predict their ability to eliminate malaria. The best compounds will be tested by scientists at [[The Scripps Research Institute]] in La Jolla, California, U.S.A. and further developed into possible treatments for the disease.<ref>{{cite web |url=http://www.worldcommunitygrid.org/research/gfam/overview.do |title=GO Fight Against Malaria Project |work=Research |publisher=World Community Grid |access-date=2013-04-11 |archive-date=2013-04-05 |archive-url=https://web.archive.org/web/20130405033145/http://www.worldcommunitygrid.org/research/gfam/overview.do |url-status=live }}</ref>

===Say No to Schistosoma===
'''Say No to Schistosoma''' (launched February 22, 2012<ref name="Say No to Schistosoma Project-WCG" />) was the 20th research project to be launched on World Community Grid. The researchers at [[Infórium University]] in [[Belo Horizonte]] and [[FIOCRUZ-Minas]], [[Brazil]], ran this project on World Community Grid to perform computer simulations of the interactions between millions of chemical compounds and certain target proteins in the hope of finding effective treatments for [[schistosomiasis]].<ref>{{cite web |url=http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=194 |title=Say No to Schistosoma |work=Research |publisher=World Community Grid |access-date=2012-05-24 |archive-date=2012-04-06 |archive-url=https://web.archive.org/web/20120406110301/http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=194 |url-status=live }}</ref> As of April 2015, subsequent analysis had been performed, and three of the most promising candidate substances had been identified for in-vitro testing.<ref name="secure.worldcommunitygrid.org" />

===Computing for Sustainable Water===
'''Computing for Sustainable Water''' was the 21st research project to be launched on World Community Grid. The researchers at the [[University of Virginia]] were running this project on World Community Grid to study the effects of human activity on a large watershed and gain deeper insights into what actions can support the restoration, health and sustainability of this important water resource.<ref>{{cite web |url=http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=198 |title=Computing for Sustainable Water |work=Research |publisher=World Community Grid |access-date=2013-05-21 |archive-date=2013-04-20 |archive-url=https://web.archive.org/web/20130420093138/http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=198 |url-status=live }}</ref> The project was launched on April 17, 2012,<ref name="CSW Launch" /> and completed on October 17, 2012.

===Uncovering Genome Mysteries===
'''The Uncovering Genome Mysteries''' project launched on October 16, 2014, and is a joint collaboration between Australian and Brazilian scientists. The project aims to examine close to 200 million genes from many life forms and compare them with known genes in order to find out what their function is. The results could have an effect in fields such as medicine and environmental research.<ref>{{cite web|url=https://secure.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=385|title=Project Launch: Uncovering Genome Mysteries|work=worldcommunitygrid.org|access-date=2014-10-24|archive-date=2014-10-24|archive-url=https://web.archive.org/web/20141024225650/https://secure.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=385|url-status=live}}</ref>

===Outsmart Ebola Together===
'''Outsmart Ebola Together''' was a collaboration with the [[Scripps Research Institute]] to help find chemical compounds to fight [[Ebola virus disease]].<ref>{{cite news|url=https://time.com/3634732/ibm-ebola-cure/|title=How Your Tablet Can Help Find an Ebola Cure|date=19 December 2014|access-date=19 December 2014|vauthors=Park A|archive-date=8 October 2016|archive-url=https://web.archive.org/web/20161008213119/http://time.com/3634732/ibm-ebola-cure/|url-status=live}}</ref> It was launched on 3 December 2014.<ref>{{cite web|url=http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=401|title=Help researchers find an Ebola cure|vauthors=Saphire EO|date=3 December 2014|access-date=20 December 2014|archive-date=20 December 2014|archive-url=https://web.archive.org/web/20141220220349/http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=401|url-status=live}}</ref> The aim is to block crucial steps in the life cycle of the virus, by finding drugs with high [[binding affinity]] with certain of its proteins. There are two targets: a surface protein used by the virus to infect human cells, and "transformer" proteins which change shape to carry out different functions.<ref>{{cite web|url=http://www.worldcommunitygrid.org/research/oet1/details.do|title=Let's outsmart Ebola together:About the Project|date=December 2014|access-date=20 December 2014|archive-date=20 December 2014|archive-url=https://web.archive.org/web/20141220211614/http://www.worldcommunitygrid.org/research/oet1/details.do|url-status=live}}</ref> The project officially completed December 6, 2018.<ref>{{cite web |url= https://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,41288 |title= Project Completed |author= <!--Not stated--> |date= 6 December 2018 |website= World Community Grid |publisher= [[IBM]] |access-date= 6 December 2018 |quote= We have completed OET. Thank you for your help and contribution towards this project. |archive-date= 30 January 2019 |archive-url= https://web.archive.org/web/20190130042554/https://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,41288 |url-status= live }}</ref>

===OpenZika===
'''OpenZika''' was launched on May 18, 2016, to help combat the [[Zika virus]]. The project targets proteins that are believed to be used by the Zika virus to survive and spread in the body, based on known results from similar diseases like [[dengue fever]] and [[yellow fever]]. These results will help researchers develop an anti-Zika drug.<ref>{{citation|url=http://www.worldcommunitygrid.org/research/zika/overview.do|title=Research: OpenZika: Project Overview|access-date=19 May 2016|archive-date=22 May 2016|archive-url=https://web.archive.org/web/20160522185942/http://www.worldcommunitygrid.org/research/zika/overview.do|url-status=live}}</ref> The project officially completed December 13, 2019.<ref>{{citation|url=https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=614|title=OpenZika's Work on World Community Grid is Complete.|access-date=2020-03-05|archive-date=2020-03-05|archive-url=https://web.archive.org/web/20200305162802/https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=614|url-status=live}}</ref>

===FightAIDS@Home===
{{Main|FightAIDS@Home}}

'''FightAIDS@Home''' (launched November 19, 2005<ref name="FightAIDSatHome-PR" />) was World Community Grid's second project and its first to target a single disease.  Each individual computer processes one potential drug molecule and tests how well it would [[docking (molecular)|dock]] with [[HIV]] [[protease]], acting as a [[Protease inhibitor (pharmacology)|protease inhibitor]].<ref name="FightAIDSatHome-WCG" /> Scripps Research Institute published its first peer-reviewed scientific paper about the results of FightAIDS@Home on April 21, 2007.<ref>{{cite journal | vauthors = Chang MW, Lindstrom W, Olson AJ, Belew RK | title = Analysis of HIV wild-type and mutant structures via in silico docking against diverse ligand libraries | journal = Journal of Chemical Information and Modeling | volume = 47 | issue = 3 | pages = 1258–62 | date = 2007-04-21 | pmid = 17447753 | doi = 10.1021/ci700044s | publisher = [[American Chemical Society]] | doi-access =free  }}</ref> This paper explains that the results up to that point will primarily be used to improve the efficiency of future FightAIDS@Home calculations.<ref>{{cite web
|url=http://fightaidsathome.scripps.edu/news/vol3.pdf
|title=FightAIDS@Home News Volume 3
|publisher=[[The Scripps Research Institute]]
|date=2007-05-10
|access-date=2007-07-30
|archive-date=2007-08-08
|archive-url=https://web.archive.org/web/20070808120748/http://fightaidsathome.scripps.edu/news/vol3.pdf
|url-status=live
}}</ref>

===FightAIDS@Home Phase 2===
'''FightAIDS@Home Phase 2''' (launched September 30, 2015<ref>{{cite web |url= https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=447 |title= Pioneering new techniques in the fight against HIV |vauthors= Olson A |date= 30 September 2015 |website= World Community Grid |publisher= IBM |access-date= 21 June 2018 |archive-date= 30 January 2019 |archive-url= https://web.archive.org/web/20190130035252/https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=447 |url-status= live }}</ref>) is looking more closely at the results of Phase 1. The project has two goals in the early experiments; the simulation architecture is functioning correctly and giving reliable results, and using BEDAM and [[AutoDock]] together provides better results than using just BEDAM or AutoDock.<ref>{{cite web |url= https://fightaidsathome2.cst.temple.edu/ |title= FightAIDS@Home - Phase II: Introduction |author= <!--Not stated--> |website= FightAIDS@Home - Phase II |publisher= College of Science and Technology Temply University |access-date= 2 July 2018 |quote= The first experiments of FightAIDS@Home Phase 2 seek to achieve two goals: first, to confirm that the new simulation schema is working as intended and gives sufficiently reliable results compared to traditionally run simulations; second, to demonstrate that using BEDAM in conjunction with AutoDock results in better predictions than using AutoDock or BEDAM alone. |archive-date= 12 April 2018 |archive-url= https://web.archive.org/web/20180412145421/https://fightaidsathome2.cst.temple.edu/ |url-status= live }}</ref>

===Microbiome Immunity Project===
'''Microbiome Immunity Project''' (launched August 2017) is a study of proteins in bacteria located in and on the human body; the [[human microbiota|human microbiome]], which comprises around 3 million separate bacterial genes. By studying bacterial genes, researchers can determine their individual shapes, which in turn dictate the function of the bacteria.<ref>{{cite web|author=<!--Not stated-->|title=Microbiome Immunity Project|url=https://www.worldcommunitygrid.org/research/mip1/overview.do|access-date=2 July 2018|website=World Community Grid|archive-date=14 August 2018|archive-url=https://web.archive.org/web/20180814221521/https://www.worldcommunitygrid.org/research/mip1/overview.do|url-status=live}}</ref> Collaborative institutions includes the [[University of California San Diego]], [[Broad Institute]] of MIT and Harvard, and the [[Simons Foundation|Simons Foundation's]] Flatiron Institute.<ref>{{cite web|date=19 June 2018|title=Microbiome Immunity Project Researchers Create Ambitious Plans for Data|url=https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=565|access-date=2 July 2018|website=World Community Grid|vauthors=Kościółek T, Taylor B|archive-date=14 August 2018|archive-url=https://web.archive.org/web/20180814223743/https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=565|url-status=live}}</ref>

===Help Stop TB===
'''Help Stop TB''' was launched in March 2016 to help combat [[tuberculosis]], a disease caused by a [[bacterium]] that is evolving resistance to currently available treatments. The computations of this project target [[mycolic acid]]s in the bacterium's protective coat, simulating the behaviour of these molecules to better understand how they offer protection to the bacteria.<ref>{{Cite web|url=https://www.worldcommunitygrid.org/research/hst1/overview.do|title=Help Stop TB|website=World Community Grid|archive-url=https://web.archive.org/web/20190619091547/https://www.worldcommunitygrid.org/research/hst1/overview.do|archive-date=June 19, 2019|url-status=live|access-date=June 19, 2019}}</ref>

===Smash Childhood Cancer===
{{Main|Smash Childhood Cancer}}

Launched in January 2017, the '''Smash Childhood Cancer''' project builds on the work from the Help Fight Childhood Cancer project by looking for drug candidates targeting additional childhood cancers.<ref>{{Cite web|url=https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=537|title=The Road Ahead for Help Fight Childhood Cancer|website=www.worldcommunitygrid.org|language=en-US|access-date=2018-03-04|archive-date=2019-01-30|archive-url=https://web.archive.org/web/20190130043514/https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=537|url-status=live}}</ref><ref>{{Cite web|url=https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=512|title=Researchers Reunite with World Community Grid to Smash Childhood Cancer|website=www.worldcommunitygrid.org|language=en-US|access-date=2018-03-04|archive-date=2019-01-30|archive-url=https://web.archive.org/web/20190130154450/https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=512|url-status=live}}</ref> Upon Dr. Akira Nakagawara's retirement in March 2020, the principal investigator changed to Dr. Godfrey Chan, who was one of the original members of the Smash Childhood Cancer team. Additionally, PRDM14 and Fox01 have been added as new targets for investigation.<ref>{{cite web |url= https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=620 |title= Smash Childhood Cancer Team Announces New Principal Investigator and New Project Targets |author= The Smash Childhood Cancer research team |date= 9 March 2020 |website= World Community Grid |publisher= [[IBM]] |access-date= 10 March 2020 |archive-date= 19 July 2020 |archive-url= https://web.archive.org/web/20200719015440/https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=620 |url-status= live }}</ref> An inhibitor of the [[Osteopontin#Cancer|osteopontin]] protein was modeled.<ref>{{Cite web |title=Research update from the SCC team (October 2022) |url=https://www.worldcommunitygrid.org/about_us/article.s?articleId=777 |access-date=2022-11-01 |website=www.worldcommunitygrid.org}}</ref>