Editing Angiosarcoma (section)

== Diagnosis ==
[[File:Cutaneous angiosarcoma (4) CD31.jpg|left|thumb|[[Immunostaining|Immunostained]] [[CD31]] in a cutaneous angiosarcoma]]
The diagnosis of angiosarcoma can be difficult due to its asymptomatic nature or non-specific symptoms. Initial diagnosis is typically done by [[Magnetic resonance imaging|MRI]], [[CT scan|CT]] or [[Medical ultrasound|ultrasound]] scan, however it is typically difficult to discern if a [[Neoplasm|mass]] is an angiosarcoma or other type of tumor such as a [[melanoma]] or [[carcinoma]]. This means that while the initial diagnosis is typically done via imaging, conclusive diagnosis has to be performed via biopsy and subsequent [[Histology|histological]] and [[Immunohistochemistry|immunohistochemical analysis]].<ref name=":0" />

The [[Tumor marker|marker]] [[CD31]] is often considered the gold standard for angiosarcoma diagnosis due to its high sensitivity and specificity. Other [[Tumor marker|markers]] typically used include [[von Willebrand factor]], [[CD34]], and [[vascular endothelial growth factor]].<ref name=":0" /> The absence of [[Tumor marker|markers]] present in [[melanoma]]s such as [[S100 protein|S100]] and [[HMB-45]] can help in differentiating angiosarcomas from [[melanoma]]s.<ref name="Angiosarcoma" />