Editing Beta cell (section)

=== Type 2 diabetes ===
Research focused on non insulin dependent diabetes encompasses many areas of interest. Degeneration of the beta cell as diabetes progresses has been a broadly reviewed topic.<ref name="Chen_2017" /><ref name="Boland_2017" /><ref name="Fu_2013" /> Another topic of interest for beta-cell physiologists is the mechanism of insulin pulsatility which has been well investigated.<ref>{{cite journal | vauthors = Nunemaker CS, Bertram R, Sherman A, Tsaneva-Atanasova K, Daniel CR, Satin LS | title = Glucose modulates [Ca2+]i oscillations in pancreatic islets via ionic and glycolytic mechanisms | journal = Biophysical Journal | volume = 91 | issue = 6 | pages = 2082–2096 | date = September 2006 | pmid = 16815907 | pmc = 1557567 | doi = 10.1529/biophysj.106.087296 | bibcode = 2006BpJ....91.2082N }}</ref><ref>{{cite journal | vauthors = Bertram R, Sherman A, Satin LS | title = Metabolic and electrical oscillations: partners in controlling pulsatile insulin secretion | journal = American Journal of Physiology. Endocrinology and Metabolism | volume = 293 | issue = 4 | pages = E890–E900 | date = October 2007 | pmid = 17666486 | doi = 10.1152/ajpendo.00359.2007 }}</ref> Many genome studies have been completed and are advancing the knowledge of beta-cell function exponentially.<ref>{{cite journal | vauthors = Muraro MJ, Dharmadhikari G, Grün D, Groen N, Dielen T, Jansen E, van Gurp L, Engelse MA, Carlotti F, de Koning EJ, van Oudenaarden A | title = A Single-Cell Transcriptome Atlas of the Human Pancreas | journal = Cell Systems | volume = 3 | issue = 4 | pages = 385–394.e3 | date = October 2016 | pmid = 27693023 | pmc = 5092539 | doi = 10.1016/j.cels.2016.09.002 }}</ref><ref>{{cite journal | vauthors = Segerstolpe Å, Palasantza A, Eliasson P, Andersson EM, Andréasson AC, Sun X, Picelli S, Sabirsh A, Clausen M, Bjursell MK, Smith DM, Kasper M, Ämmälä C, Sandberg R | title = Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes | journal = Cell Metabolism | volume = 24 | issue = 4 | pages = 593–607 | date = October 2016 | pmid = 27667667 | pmc = 5069352 | doi = 10.1016/j.cmet.2016.08.020 }}</ref> Indeed, the area of beta-cell research is very active yet many mysteries remain.