Editing Cluster headache (section)

===Verapamil===
The recommended first-line preventive therapy is [[verapamil]], a [[calcium channel blocker]].<ref name=AFP2013/><ref name=EFNS>{{cite journal |doi=10.1111/j.1468-1331.2006.01566.x |pmid=16987158 |title=EFNS guidelines on the treatment of cluster headache and other trigeminal-autonomic cephalalgias |journal=European Journal of Neurology |volume=13 |issue=10 |pages=1066–77 |year=2006 |last1=May |first1=A. |last2=Leone |first2=M. |last3=Áfra |first3=J. |last4=Linde |first4=M. |last5=Sándor |first5=P. S. |last6=Evers |first6=S. |last7=Goadsby |first7=P. J. |doi-access=free }}</ref> Verapamil was previously underused in people with cluster headache.<ref name=Beck/>
Improvement can be seen in an average of 1.7 weeks for episodic cluster headache and 5 weeks for chronic cluster headache when using a dosage of ranged between 160 and 720&nbsp;mg (mean 240&nbsp;mg/day).<ref name="vera">{{cite journal |vauthors=Petersen AS, Barloese MC, Snoer A, Soerensen AM, Jensen RH | title =Verapamil and Cluster Headache: Still a Mystery. A Narrative Review of Efficacy, Mechanisms and Perspectives | journal =Headache| date = 2019 | volume =59| issue =8| pages =1198–1211| pmid = 31339562| doi = 10.1111/head.13603| s2cid =198193843 }}</ref> Preventive therapy with verapamil is believed to work because it has an effect on the circadian rhythm and on CGRPs as CGRP-release is controlled by voltage-gated calcium channels.<ref name="vera"/>